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DDT, Dicofol, infant mortality
I thought that a limited topic like polio vaccines wasn’t too much information, but it looks like there’s a sheer limitless amount of dirt...
In 1972, in the US DDT was prohibited, but instead they continued to produce “dicofol” (a.k.a. Kelthane), which is really DDT in disguise.
K. Paul Stoller – AD, AFP, ALS, and DDT (2015): http://journalijcar.org/sites/default/files/issue-files/0151.pdf
(archived here: http://archive.is/QmJa7)
Stoller refers to a nice paper describing research by the US Army Medical Research and Development Command (with MIT) that shows that at the 20 and 40 μg levels of DDT, the yield of polio virus per cell was increased 37 and 90%, respectively. It is reasonable to postulate that it could also increase the replication of other viruses.
Also look for Kelthane (that replaced DDT) which increases the yield of the polio virus with a whopping 430%...
J. Gabliks – Studies of Biologically Active Agents in Cells and Tissue Cultures (1967): http://www.dtic.mil/dtic/tr/fulltext/u2/804387.pdf
(archived here: http://archive.is/b7CDg)
The following study writes about a previous study, where the Oral Polio Vaccine (OPV) raised the death rate in children (only significant for boys). But this couldn’t be repeated in this study.
This study in Guinea-Bissau is the only in its kind. Can anybody think of any reason for why big pharma wouldn’t research that the polio vaccines causes death…
This study could be completely worthless, as it wasn’t single blind (let alone double blind) and there are also admitted effects that there were other ongoing polio vaccination campaigns, for which the data was manipulated (censored); the study doesn’t describe how it was “censored” (I can’t remember that in the course statistics that I followed at university “censoring” was mentioned...).
Najaaraq Lund et al – The Effect of Oral Polio Vaccine at Birth on Infant Mortality: A Randomized Trial (2015): https://academic.oup.com/cid/article/61/10/1504/302404/The-Effect-of-Oral-Polio-Vaccine-at-Birth-on
(archived here: http://archive.is/LfMUk )
Also see the rising numbers in reported AFP cases from 1993 to 1995 in Cambodia, China, Lao PDR, Philippines, in the 6 countries totally from 2674 to 5644 (more than double in 2 years).
Rudolf H. Tangerman et al – Poliomyelitis Eradication in the Western Pacific Region (1997):
https://www.google.nl/url?sa=t&rct=...ll.pdf&usg=AFQjCNEa_S8s7B7lQ7QiTcPDCSM3hhCOWA
(archived here: http://archive.is/mhrzS)
I thought that a limited topic like polio vaccines wasn’t too much information, but it looks like there’s a sheer limitless amount of dirt...
In 1972, in the US DDT was prohibited, but instead they continued to produce “dicofol” (a.k.a. Kelthane), which is really DDT in disguise.
K. Paul Stoller – AD, AFP, ALS, and DDT (2015): http://journalijcar.org/sites/default/files/issue-files/0151.pdf
(archived here: http://archive.is/QmJa7)
DDT was/is used in the United States to control insects in crops and livestock and to combat insect-borne diseases. It was introduced as a pesticide during WWII. In the United States, the general use moratorium took place in 1972, but there is another pesticide dicofol, which is made and sold by Dow AgroSciences and carries the trademark KELTHANE® , is in fact DDT. In China dicofol is produced by the Yangzhou Pesticide Factory, which reports production quantities of 4 million pounds of dicofol per year.
(…)
This class of insecticide (organochlorine) impacts the electrical activity in the body, so it affects brain and heart, but also there are other organs that use electrical current, including the lungs. It clearly affects the immune system and causes cancer, and the best part is that it doesn’t break down in the environment other than to become DDE (and DDD).
(…)
India, which manufactures and uses the most DDT, was declared free of polio in 2011, but cases of AFP have skyrocketed.
Stoller refers to a nice paper describing research by the US Army Medical Research and Development Command (with MIT) that shows that at the 20 and 40 μg levels of DDT, the yield of polio virus per cell was increased 37 and 90%, respectively. It is reasonable to postulate that it could also increase the replication of other viruses.
Also look for Kelthane (that replaced DDT) which increases the yield of the polio virus with a whopping 430%...
J. Gabliks – Studies of Biologically Active Agents in Cells and Tissue Cultures (1967): http://www.dtic.mil/dtic/tr/fulltext/u2/804387.pdf
(archived here: http://archive.is/b7CDg)
insecticidal compounds DDT, chlordane, Kelthane , Dipterex malathion, and Karathane at subtoxic concentrations inhibited vaccinia virus replication in human Chang liver cellq. Under the same experimental conditions, the replication of poliovirus was inhibited only by chlordane and malthion, whereas Kelthane increased the virus yields 4 and 18 times, respectivaly, and DDT exhibited a slight stimulatory effect.
(…)
The studies described in the Annual Progress Report of 1965 indicated that human HeLa cells exposed to subtoxic concentrations of the insecticidal compounds, CygonR, DipterexR, DI-SystonR, chlordane and Karathane for 84 days were more susceptible to poliovirus infection than the corresponding control cells (1,2).
As it is recognized that residues of some agricultural insecticides persist in the body and that cells are continuously exposed to their metabolites, we investigated the possibility that these chemicals may alter certain physiological activities of cells and subsequently influence the susceptibility of hosts to virus infections.
The effects of organophosphorus, organochlorine and dinitrophenol insecticidal compounds on the replication of polio and of vaccinia viruses were studied in human Chang liver cells, using purified or analytical grade comnounds obtained from their manufacturers.
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In the poliovirus test the cell response was not uniform. In comparison to the controls, the virus yield in the DDT-treated cultures was slightly increased; the yield in the chlordane and malathion cultures was reduced (32 and 18% of the controls); and the yield in the Kelthane and Karathane cultures was greatly increased (430 and 1800% respectively).
(…)
The stimulatorv effect by DDT, Kelthane, and Karathane on poliovirus replication suggests a possibility that these compounds may have some specific effects on the mechanisms of viral biosynthesis. This possibility is supported by the results of our previous report which indicated an increased yield of poliovirus in HeLa cells exposed to Karathane for 77 days(2).
(…)
Appendix Number 1
EFFECTS OF INSECTICIDAL COMPOUNDS ON THE REPLICATION OF JACCINIA AND POLIO VIRUSES IN HUMAN CHANG LIVER CELLS
Janis Gabliks
(…)
To investiqate the effects of insecticidal comuounds on viral virus replication, we tested six insecticidal compounds in human liver cells infected with vaccinia and poliovirus.
(…)
In the presence of 20 and 40 μg levels of DDT, poliovirus yield per culture was comparable to that of the control. However, when the yield of infectious virus released is expressed per individual cell or per ig of cell protein, as shown in Figure 3, it is evident that at the 20 and 40 μg levels of DDT, the yield of virus per cell was increased 37 and 90%, respectively. Similarly, the yield per μg of protein was also increased 15 and 47%, respectively
(…)
In contrast to the inhibitory action of these two insecticides, the Kelthane-treated cultures produced about four times more virus, and the Karathane-treated cells 18 times more virus than the corresponding controls.
(…)
The stimulatory effect by DDT, Kelthane, and Karathane on poliovirus replication suggests a possibility that these compounds may have some specific effects on the mechanisms of viral biosynthesis, and the state of some latent viruses may also be altered. This possibility is supported by the results of our previous report which indicated an increased yield of poliovirus in HeLa cells, chronically exposed to Karathane for 77 days (7,8).
The following study writes about a previous study, where the Oral Polio Vaccine (OPV) raised the death rate in children (only significant for boys). But this couldn’t be repeated in this study.
This study in Guinea-Bissau is the only in its kind. Can anybody think of any reason for why big pharma wouldn’t research that the polio vaccines causes death…
This study could be completely worthless, as it wasn’t single blind (let alone double blind) and there are also admitted effects that there were other ongoing polio vaccination campaigns, for which the data was manipulated (censored); the study doesn’t describe how it was “censored” (I can’t remember that in the course statistics that I followed at university “censoring” was mentioned...).
Najaaraq Lund et al – The Effect of Oral Polio Vaccine at Birth on Infant Mortality: A Randomized Trial (2015): https://academic.oup.com/cid/article/61/10/1504/302404/The-Effect-of-Oral-Polio-Vaccine-at-Birth-on
(archived here: http://archive.is/LfMUk )
Background. Routine vaccines may have nonspecific effects on mortality. An observational study found that OPV given at birth (OPV0) was associated with increased male infant mortality.
(…)
A supplementation conducted from 2002 to 2004 in Guinea-Bissau, the country experienced a period with a shortage of OPV; a total of 962 trial participants did not receive the recommended OPV0. Surprisingly, boys who missed OPV0 had significantly lower infant mortality compared with boys who received OPV0 (adjusted mortality rate ratio [MRR], 0.35 [95% confidence interval {CI}, .18–.71]) [24]. The tendency was opposite for girls (adjusted MRR, 1.14 [95% CI, .70–1.89]); thus, the effect of OPV0 differed significantly between boys and girls (P = .006). Receiving OPV0 was also associated with reduced immune responses to BCG in both sexes [25].
(...)
Children randomized to OPV received 2 drops of the vaccine orally immediately after randomization. There was no placebo or blinding. Guinea-Bissau does not have a central vaccination registry, so it was important that the vaccination card contained the correct information if a child moved from the HDSS area.
(…)
The main outcome was overall mortality (excluding accidents) within the first 12 months of life. In addition, we analyzed the “pure” effect of OPV0 on survival from enrollment to age 6 weeks, before controls were likely to receive the first routine OPV.
Furthermore, the protocol specified that if large campaigns were conducted during follow-up, analyses would also be conducted with censoring for such campaigns. Thus, we analyzed the impact on infant mortality with censoring for subsequent national OPV campaign, as OPV campaigns could potentially neutralize any differential effect of OPV0. During the conduct of the trial, there was also a national MV campaign (December 2009) and an H1N1 vaccine campaign (October 2010), both targeting children aged 6 months to 5 years. In additional analyses, we censored for these campaigns.
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Based on previous observations [31], we anticipated an infant mortality rate of 50 per 1000 participants. However, during the study period, infant mortality declined to 26 per 1000 person-years. This reduced the power to detect a difference between groups. An interim report for the DSMB showed significantly higher mortality among children randomized to BCG only. As this was in favor of current policy, the DSMB recommended that the number of participants not be increased to compensate for the lower mortality.
(...)
Table 2.
Infant Mortality Rates and Hazard Ratios for Children Randomized to BCG Plus Oral Polio Vaccine at Birth or BCG Only, Guinea-Bissau, 2008–2011
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(…)
Within censoring for OPV campaigns (mean duration of follow-up = 163 days), 41 died in the BCG + OPV0 group and 60 died in the BCG-only group.
(...)
Contrary to our initial hypothesis, both male and female children who received OPV0 with BCG tended to have better survival than those who received BCG only. As in a previous study, receiving OPV0 within the first days of life appeared to be associated with the strongest benefits. Many OPV campaigns occurred during the trial; when censoring for these campaigns, the beneficial effect of receiving OPV0 was borderline significant overall and significant separately in males.
(...)
A weakness of our study is that it was not blinded. However, health workers in the area were unaware of the study hypothesis and were unlikely to be influenced when treating the children. The outcome assessment was carried out by assistants unaware of the vaccination allocation. Hence, we do not believe that the lack of blinding affected the results.
In addition, national OPV campaigns could have led to environmental acquisition in children born in the period after a campaign. It is likely that, in a population-dense urban setting, indirect vaccination also occurs in the absence of OPV campaigns, through close contact with newly vaccinated children. This exposure, if anything, would be expected to dilute any differences between children who received OPV0 or no OPV0.
All background factors were evenly distributed between the 2 randomization groups and did not confound the results. OPV0 had the best effect among children enrolled early. Early enrollment could be a proxy for better socioeconomic status, as it is typically the more wealthy mothers who delivered at the maternity ward and were enrolled early.
(...)
In 2004 there were several campaigns, and none in 2007, but many during the present trial. Censoring for these campaigns made the results more comparable, as OPV0 tended to be most beneficial before additional OPV was given in campaigns.
Also see the rising numbers in reported AFP cases from 1993 to 1995 in Cambodia, China, Lao PDR, Philippines, in the 6 countries totally from 2674 to 5644 (more than double in 2 years).
Rudolf H. Tangerman et al – Poliomyelitis Eradication in the Western Pacific Region (1997):
https://www.google.nl/url?sa=t&rct=...ll.pdf&usg=AFQjCNEa_S8s7B7lQ7QiTcPDCSM3hhCOWA
(archived here: http://archive.is/mhrzS)

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