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Bradford Hill, Knoweldon - Inoculation and Poliomyelitis
Of 340 cases of reported “poliomyelitis” investigated from Melbourne, Australia, 31 had received an injection of diphtheria toxoid or pertussis vaccine, within three months of the onset of the paralysis.
The paralysis was significantly more frequent in the limbs in which they were vaccinated.
In the 17 of them younger than 3 years that had been vaccinated in the preceding 35 days, the severity of the paralysis was greater in the last inoculated limbs than in a comparable group of children not recently vaccinated.
The site of paralysis frequently coincided with the site of injection at given intervals.
Table IV shows that, of the children who had been vaccinated in the month preceding the paralysis, 81% had paralysis in the limb of injection. This proportion is much higher than for children whose last injection was 1 to 6 months before – that involved the limb of injection in 25%, and when it was longer than 6 months before 15 %.
Table V shows for the 7 older children with paralysis a similar significant difference.
Four of these children (57%) had paralysis in the limb of injection, but for the large group whose vaccination was more than 6 months distant only 10% showed an association of the sites of injection and paralysis.
In the 1949 epidemic of polio in Australia, paralysis was associated with inoculation procedures in the month preceding the recorded date of onset of paralysis. But no such effect was observed for vaccinations 3 or more months before the start of illness.
A. Bradford Hill, J. Knoweldon – Inoculation and Poliomyelitis (1950): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2038021/
Of 340 cases of reported “poliomyelitis” investigated from Melbourne, Australia, 31 had received an injection of diphtheria toxoid or pertussis vaccine, within three months of the onset of the paralysis.
The paralysis was significantly more frequent in the limbs in which they were vaccinated.
In the 17 of them younger than 3 years that had been vaccinated in the preceding 35 days, the severity of the paralysis was greater in the last inoculated limbs than in a comparable group of children not recently vaccinated.
The site of paralysis frequently coincided with the site of injection at given intervals.
Table IV shows that, of the children who had been vaccinated in the month preceding the paralysis, 81% had paralysis in the limb of injection. This proportion is much higher than for children whose last injection was 1 to 6 months before – that involved the limb of injection in 25%, and when it was longer than 6 months before 15 %.
Table V shows for the 7 older children with paralysis a similar significant difference.
Four of these children (57%) had paralysis in the limb of injection, but for the large group whose vaccination was more than 6 months distant only 10% showed an association of the sites of injection and paralysis.
In the 1949 epidemic of polio in Australia, paralysis was associated with inoculation procedures in the month preceding the recorded date of onset of paralysis. But no such effect was observed for vaccinations 3 or more months before the start of illness.
A. Bradford Hill, J. Knoweldon – Inoculation and Poliomyelitis (1950): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2038021/