Not one single GLOCK fanboy yet?
So let me tell ya... I am NOT a glock fanboy. I don't like 'em.
However, when I leave the house, the gun that comes with me is a GLOCK 26.
When you have your wife try out different guns, make sure the GLOCK 19 is on the list. Any place that rents handguns will have one. Period. And that says something.
When I was looking for my EDC I listed my priorities.
1) Has to be able to stop a man. 9x19 will stop a man. As already stated earlier, 38 spcl will stop a man too, and 38 has less ass behind it than 9 luger. These rounds may not be able to instakill a large, determined attacker with one shot to the toenail. However, this is an economic exercise. The likelihood that you'll be attacked is very low. The likelihood that five shots of 38spcl not ending the attack is (provided you hit) also very low. Remember, it's possible to jump out of a plane at 30,000 feet without a parachute and live. That doesn't mean we necessarily plan for it.
2) I wanted to be able to double-tap easily. That mandated 9x19. True, I could practice with 40 or 45 and get to the point of being able to do it, but I'm not made of money, which brings us to...
3) I needed to be able to practice with it. You may be looking at firing 3-4 boxes of ammo before getting to the point of being able to reliably hit a pie plate at 7 feet. Do you want that to cost $50, or do you want it to cost $200?
4) I needed a round I would be likely to find, no matter what happens with supply chains, laws, or economic conditions, for the duration of my life. The round that practically every military on the planet carries in their sidearms seemed to be a good choice.
5) I needed to be able to find holsters, sights, extra magazines, extended slide stops, reduced trigger pull kits, repair parts, etc. Go buy a gun nobody's heard of like a Steyr M and fall totally in love with it, and then try to find a holster, and you'll understand the importance of aftermarket support.
6) It needed a good body of online tutorials and youtube videos showing how to use it, how to trick it out, etc.
7) May be unrelated to your requirements, but I had to be able to conceal it easily, and be able to put it in the front pocket of baggy pants.
Now back on topic, this is not what's next to my bed. That's a stainless 4" barrel S&W 681 6-shot 357 magnum revolver. The reason is my wife has rheumatoid arthritis and has actual physical trouble with slides. With her it's a medical issue: most women can adopt different techniques and rack a slide easily, but if you don't have a whole lot of cartilage in your wrist those techniques don't matter.
Nevertheless, a lot of people like shooting medium/full frame revolvers because there's a big damn fireball coming out of the front and it doesn't kick as much as semi-autos.
Last thought: before I had the Smith I had a 4" Ruger GP-100 which, coincidentally, I picked up used for exactly $300, and which I regret trading for the Smith at this point. The Smiths have MUCH better triggers, it's true. But not nearly good enough to make up for the lack of cusion on the backstrap.