Hillary will net benefit, because as established in past cycles, after some midterm gains, Republicans will pridefully think they can coast into the White House by pushing yet another milquetoast moderate who alienates their own base. Marquee example was 2010---after the Democrats got the worst midterms congressional beating in 150 years, and with the whole country speaking as one to repeal Obamacare, the GOP nominated the one candidate who was the most fatally flawed on the issue (Romney, of Romneycare).
So, buoyed by the complete takeover of Congress in this election, with the damaged brand called Hillary on the horizon, the Republican leadership will no doubt push for the even more damaged Bush as its standard bearer come 2016.