The need for vitamin C changes as stress on the body changes. One never knows exactly how much is needed on any given day.
I agree there needs to me more research done as to the optimal dosage of vitamin C. The major problem is, who is going to pay for the research when there are so many drug companies who would rather make money from the patent drugs they make? Regular cholesterol is not what causes heart disease. Lipoprotein(a) cholesterol is what really causes heart disease. When there is damage to the arterial wall and a lack of collagen to repair the damage, the Lp(a) acts as a surrogate to repair the damage.
In a damaged arterial wall, there are exposed lysine and proline residues where the Lp(a) finds binding sites. When Lp(a) is already bound with lysine and proline, the binding sites on the arterial wall are no longer needed because the Lp(a) already has all of it's binding sites filled. The extra vitamin C is converted to collagen and the wall of the artery is repaired.
More can be found on this subject at this web site:
http://www.healthvision2020.com/heartdisease.html
I take four grams of vitamin C, four times a day. I also take two grams of L-Lysine and 500 mg of L- Proline whenever I take the vitamin C.