What fringy stuff? Okay, there's some, but the NAU is a BIG issue for a lot of people.
The readership of USA Today is cosmopolitan, business-oriented, and includes a LOT of people who are traveling and who aren't afraid of the rest of the world.
The two issues that are going to be a turn-off to such a reader are the lack of clarity on trade and the negative tone of the discussion of immigration
(1) It should include a statement that Ron Paul is FOR free trade, rather than just a promise to repeal all the trade agreements of the past decade: which by itself sounds like the anti-globalist movement and a strong threat to the type of reader who gets USA Today at his hotel. Point out that managed trade isn't free trade: don't condemn free trade (Ron Paul certainly doesn't do so, and is far more careful in his statements to not sound like an isolationist on trade, as this ad sounds). Use Paul's favorite Jefferson quote supporting "peace, commerce, and honest friendship with all nations."
(2) If we scan skip abortion, we can skip immigration. A business reader told Paul is going to end illegal immigration is going to think (a) SURE he is, (b) I'm having trouble getting qualified workers as it is, and (c) he probably is going to support crackdowns on business hiring and add to my regulatory burden. This is the WORST possible audience to press on immigration: the USA today readers are far and away the most libertarian on immigration. If the ad must address it, the tone should be more positive: (a) end the welfare state and return to an America which attracts people who want opportunity rather than free benefits and (b) reform immigration to welcome those who play by the rules and not reward those who don't. I'd prefer a judicious deletion of the entire immigration topic from this ad, given its audience, but at least let's not drive them away with a fear-filled treatment of the topic. Others have already pointed out that "ending birthright citizenship" is a terrible way to address the subject, and I agree.
Overall, too many topics and too much of a laundry list: his appeal to the USA Today crowd will come from his non-interventionism, sound economic policies, and protection of civil liberties. Appeals that sound anti-globalist and anti-immigrant will dilute and harm the message for the USA Today audience, and make the piece less readable and positive. If we're going to be prudent, let's be prudent.
Like others, my great appreciation to Mr. Lepard for this potentially great contribution to the success of the campaign. My focus on criticism should not be taken as my opinion of the ad: I love most of it, and am focusing on where I think it can be improved for efficiency reasons.