I highly doubt that. Dopey old Ben Carson got 10% just by declaring himself anti-establishment and then falling asleep. Ron would have done much better than him. Rand failed because he ran as an Establishment candidate in the most anti-establishment year on record and the establishment felt they had better options (and they did, because guys like Rubio, Kasich, and Jeb are far more establishment than Rand).
For a liberty candidate to win, he basically has to run as a more electable version of Ron Paul. That is the formula Rand Paul followed quite successfully in 2010. Not sure why he ditched it this time.
If Bernie Sanders, Ted Cruz, and Donald Trump were running when Ron did he would never have gotten past 1%. If ISIS started beheading people when Ron was running, he never would have gotten 1%. Rand's campaign was far more polished, had far better presence, and was run much better than Ron's.