Paxlovid: Pfizer says COVID-19 pill almost 90% effective preventing severe illness, death

[Brian4Liberty]

Pfizer says COVID-19 pill almost 90% effective preventing severe illness, death

Nov. 5 (UPI) -- Pharma company Pfizer announced on Friday that its experimental, antiviral COVID-19 treatment pill Paxlovid showed during testing that it's almost 90% effective in preventing hospitalization and death in high-risk patients.

The company said when combined with a low dose of ritonavir and taken within five days of the onset of symptoms, it cut severe illness and death attributed to the coronavirus by 89%.

"Today's news is a real game-changer in the global efforts to halt the devastation of this pandemic," Pfizer CEO Albert Bourla said in a statement.
...
More: https://www.upi.com/Top_News/US/2021/11/05/pfizer-covid-pill-paxlovid/9781636113852/

 

[Brian4Liberty]

Major news from our pharma spokesman in chief:

Biden says U.S. has secured doses of new Pfizer COVID pill

WASHINGTON (Reuters) - President Joe Biden said on Friday that the United States has secured millions of doses of Pfizer Inc's experimental antiviral pill for COVID-19 in case it turns out to be an effective treatment.

"If authorized by the FDA we may soon have pills that treat the virus in those who become infected," Biden said. "We've already secured millions of doses. The therapy would be another tool in our toolbox to protect people from the worst outcomes of COVID."
...
More: https://www.msn.com/en-us/news/poli...red-doses-of-new-pfizer-covid-pill/ar-AAQmHBm

 

[Brian4Liberty]

Paxlovid is a 3CL Protease Inhibitor, a type of drug commonly used to treat AIDS.

It's unclear if this is a repurposed drug or new formulation. Various 3CL Protease Inhibitors have been under investigation for a while now:

Identification of SARS-CoV-2 3CL Protease Inhibitors

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emphasized the urgency to develop effective therapeutics. Drug repurposing screening is regarded as one of the most practical and rapid approaches for the discovery of such therapeutics. The 3C-like protease (3CLpro), or main protease (Mpro) of SARS-CoV-2 is a valid drug target as it is a specific viral enzyme and plays an essential role in viral replication. We performed a quantitative high-throughput screening (qHTS) of 10 755 compounds consisting of approved and investigational drugs, and bioactive compounds using a SARS-CoV-2 3CLpro assay. Twenty-three small molecule inhibitors of SARS-CoV-2 3CLpro have been identified with IC50s ranging from 0.26 to 28.85 μM. Walrycin B (IC50 = 0.26 μM), hydroxocobalamin (IC50 = 3.29 μM), suramin sodium (IC50 = 6.5 μM), Z-DEVD-FMK (IC50 = 6.81 μM), LLL-12 (IC50 = 9.84 μM), and Z-FA-FMK (IC50 = 11.39 μM) are the most potent 3CLpro inhibitors. The activity of the anti-SARS-CoV-2 viral infection was confirmed in 7 of 23 compounds using a SARS-CoV-2 cytopathic effect assay. The results demonstrated a set of SARS-CoV-2 3CLpro inhibitors that may have potential for further clinical evaluation as part of drug combination therapies to treating COVID-19 patients and as starting points for chemistry optimization for new drug development.
...
https://pubmed.ncbi.nlm.nih.gov/33062953/

 

[69360]

Problem is that if they have an effective drug to treat it, they will lose the temporary approval for the vax. Will be intersting to see how that plays out. They will probably just change the rules and move the goalposts yet again.

 

[Brian4Liberty]

Problem is that if they have an effective drug to treat it, they will lose the temporary approval for the vax. Will be intersting to see how that plays out. They will probably just change the rules and move the goalposts yet again.

Maybe they will reclassify the vax as a "prophylactic treatment".

 

[RJB]

This might be a better moneymaker than vaccines. The government pays Pfizer to give everyone in America these pills for "free." Most Americans will throw them in the trash and say they took the drugs and Pfizer keeps the cash

 

[jkr]

 

[Anti Globalist]

Me thinks this experimental pill is dangerous.

 

[BortSimpson]

Weren't we told that the original vaccine was 100% effective in preventing death and hospitalization?

 

[jmdrake]

Let me guess. You can get out of the vaccine mandate as long as you promise to buy Pfizer's antiviral drug. Ammiright? Way to cover your bases Pfizer.

 

[Murray N Rothbard]

If it's as good as they say, it shouldn't have a patent restricting it.

 

[enhanced_deficit]

Dr Gottlieb, nbc biz channel resident expert on all things covid, has pretty much declared that the latest Pfizer pill marks the end of the end of covid.

[h=1]Pfizer board member Gottlieb says the Covid pandemic could be over in the U.S. by January[/h]
Published Fri, Nov 5

Gottlieb’s comments came in the wake of data from Pfizer that indicated its Covid antiviral pill, when paired with an HIV medication, slashed the potential for hospitalization or death by 89% in adults at risk for severe complications. Combining the pill with an HIV medication slowed the metabolism, allowing the Covid antiviral to work longer in the body.

Pfizer CEO Albert Bourla said in an interview Friday morning with “Squawk Box” before Gottlieb spoke that the company will submit data on the therapeutic to the FDA before Thanksgiving.


cnbc.com/2021/11/05/pfizer-board-member-gottlieb-says-the-covid-pandemic-could-be-over-in-the-us-by-january-.html

 

[AngryCanadian]

Maybe the ceo of Pfizer should take it if its "safe"

 

[cjm]

I like this news. For those that are terrified of the 'rona and want to get the jab, or worse, jab their kids, there's a new story: "don't risk the jab, just take this pill if you get sick" It buys time for more jab info to get out, and more natural/established remedies can be tried before taking this experiment.

I mentioned on another thread that I've kind of given up with the anti-jab messaging. But to clarify, I've given up on consenting adults. I'm still lobbying the jab-happy against jabbing their kids.

 

[dannno]

It's basically Ivermectin.

 

[Brian4Liberty]

It's basically Ivermectin.

It would be nice if he addressed the big difference between Ivermectin and Paxlovid.

Paxlovid is a combination of two drugs. So it’s like Ivermectin plus another drug. The secondary drug is Ritonavir, which is used with a lot of combination therapies. Ritonavir slows down metabolism of the other drug, thus increasing it’s time, concentration and effectiveness in the body. It also has a lot of adverse effects.

The question would be does Ivermectin have a drug that helps it work better? The FLCCC certainly has a lot of supplements and drugs in their protocol that go along with Ivercmectin. It would be interesting to hear which ones play a role similar to what Ritonavir does, in other words, helping make Ivermectin more bioavailable.

 

[pcosmar]

It's the Pax

G-23 Paxilon Hydrochlorate or "Pax" was a chemical compound added to the air processors in order to pacify the populace, by the Union of Allied Planets. An Alliance research team on Miranda discovered that the Pax was effective with 99.9% of people. It was such an effective means of pacifying that the people stopped doing anything, they simply waited ...

 

[Brian4Liberty]

Media and officials are really pushing this drug now. So nice of them to finally approve of a treatment modeled after Ivermectin. Sorry about all those avoidable deaths that occured while they worked to come up with a patented and expensive alternative to Ivermectin.

 

[Murray N Rothbard]

Media and officials are really pushing this drug now. So nice of them to finally approve of a treatment modeled after Ivermectin. Sorry about all those avoidable deaths that occured while they worked to come up with a patented and expensive alternative to Ivermectin.

Completely different proposed mechanisms of action.

Paxlovid is a protease inhibitor, meaning it directly inhibits the key enzyme the virus RNA codes for off the bat that is used to chop up the rest of its RNA into individual bits for specific proteins. Without this enzyme, the virus can't hijack human ribosomes to make its own proteins and replicate. Protease inhibitors have been around for a while. If you look around on youtube you will find protease inhibitor videos from pre-Covid years modeling with molecular docking simulations how it works.

Ivermectin does not have a well understood mechanism. In vitro, ie in a petri dish in a lab, at very high concentrations it's been shown to affect the virus's binding of surface proteins and to also bind transport proteins in the cell. In human studies the concentrations of the medication are nowhere near this level, and it is thought to be more of an anti-inflammatory. No randomized placebo controlled trials have yet found legitimate evidence of benefit compared to placebo.

https://www.youtube.com/watch?v=XTTuUa6Di-c

 

[GlennwaldSnowdenAssanged]

Pharmaceuticals via injection or mouth are still pharmaceuticals.