Paxlovid: Pfizer says COVID-19 pill almost 90% effective preventing severe illness, death

[Brian4Liberty]

Completely different proposed mechanisms of action.

Paxlovid is a protease inhibitor, meaning it directly inhibits the key enzyme the virus RNA codes for off the bat that is used to chop up the rest of its RNA into individual bits for specific proteins. Without this enzyme, the virus can't hijack human ribosomes to make its own proteins and replicate. Protease inhibitors have been around for a while. If you look around on youtube you will find protease inhibitor videos from pre-Covid years modeling with molecular docking simulations how it works.

Ivermectin does not have a well understood mechanism. In vitro, ie in a petri dish in a lab, at very high concentrations it's been shown to affect the virus's binding of surface proteins and to also bind transport proteins in the cell. In human studies the concentrations of the medication are nowhere near this level, and it is thought to be more of an anti-inflammatory. No randomized placebo controlled trials have yet found legitimate evidence of benefit compared to placebo.

https://www.youtube.com/watch?v=XTTuUa6Di-c

Yep. Already posted about this new drug being a protease inhibitor:

Paxlovid is a 3CL Protease Inhibitor, a type of drug commonly used to treat AIDS.

It's unclear if this is a repurposed drug or new formulation. Various 3CL Protease Inhibitors have been under investigation for a while now:

Identification of SARS-CoV-2 3CL Protease Inhibitors

The following video is informative. Around the 11:20 mark, he talks about how Ivermectin also has 3CL Protease inhibition qualities.

It's basically Ivermectin.

Now if we want to discuss the bioavailability and concentration of the two drugs, that is also of interest. The new Pfizer drug is a combination drug, with another off-patent drug added. That off-patent addition, Ritonavir, is used to increase the availability of the other drug in the body.

So if the bio-concentration and availability are also an issue with Ivermectin (theoretically), why not combine Ivermectin with Ritonavir? Could it be that both drugs are off patent, and would not be as profitable? Pharma companies have held back life saving drugs in the past because they had to wait for more profitable, patented substitutes. This happened with a Hepatitis C cure, which was held back while people died.

Of course this new combination would not be necessary if Ivermectin in combination with Quercetin and Zinc is already effective. Those who actually treat patients believe that it is already effective. I am in no position to question them.

It would be nice if he addressed the big difference between Ivermectin and Paxlovid.

Paxlovid is a combination of two drugs. So it’s like Ivermectin plus another drug. The secondary drug is Ritonavir, which is used with a lot of combination therapies. Ritonavir slows down metabolism of the other drug, thus increasing it’s time, concentration and effectiveness in the body. It also has a lot of adverse effects.

The question would be does Ivermectin have a drug that helps it work better? The FLCCC certainly has a lot of supplements and drugs in their protocol that go along with Ivercmectin. It would be interesting to hear which ones play a role similar to what Ritonavir does, in other words, helping make Ivermectin more bioavailable.

 

[Warrior_of_Freedom]

that's higher than the "vaccine" Governor Murphy even admitted 47% of new hospital admissions got the shot, but then double downed on looking like a gopher by shaming people who didn't get their boosters.

 

[Brian4Liberty]

Pfizer pill becomes 1st US-authorized home COVID treatment

WASHINGTON (AP) — U.S. health regulators on Wednesday authorized the first pill against COVID-19, a Pfizer drug that Americans will be able to take at home to head off the worst effects of the virus.

The long-awaited milestone comes as U.S. cases, hospitalizations and deaths are all rising and health officials warn of a tsunami of new infections from the omicron variant that could overwhelm hospitals.

The drug, Paxlovid, is a faster way to treat early COVID-19 infections, though initial supplies will be extremely limited. All of the previously authorized drugs against the disease require an IV or an injection.

An antiviral pill from Merck also is expected to soon win authorization. But Pfizer's drug is all but certain to be the preferred option because of its mild side effects and superior effectiveness, including a nearly 90% reduction in hospitalizations and deaths among patients most likely to get severe disease.

“The efficacy is high, the side effects are low and it’s oral. It checks all the boxes,” said Dr. Gregory Poland of the Mayo Clinic. “You’re looking at a 90% decreased risk of hospitalization and death in a high-risk group — that’s stunning.”
...
More: https://www.sfgate.com/news/article/Pfizer-pill-becomes-1st-US-authorized-home-COVID-16722697.php

 

[RJB]

How the hell do they get away with putting percentages on these. I have never seen drugs advertised like this before. How can they say "that it's almost 90% effective in preventing hospitalization and death in high-risk patients."

I have never seen, "Prozac is almost 90% effective in preventing debiliating depression and suicide in those at risk for severe depression." ??????

 

[Brian4Liberty]

How the hell do they get away with putting percentages on these. I have never seen drugs advertised like this before. How can they say "that it's almost 90% effective in preventing hospitalization and death in high-risk patients."

I have never seen, "Prozac is almost 90% effective in preventing debiliating depression and suicide in those at risk for severe depression." ??????

The answer to that is probably in the title and the first line:

“U.S. health regulators on Wednesday authorized”

Anything is possible when you are part of the “authorized” and approved crony pharma-industrial complex.

 

[GlennwaldSnowdenAssanged]

Will Pfizer be at the SCOTUS to say we do not have a pandemic because they have treatment?

 

[AngryCanadian]

They sure enjoy that 90% number dont they do?

 

[Brian4Liberty]

Recipients of Biden-touted Paxlovid report Covid symptoms returning and even testing positive for the virus again after completing course of the drug

Paxlovid has been deemed one of the gold standard Covid treatments in the U.S., even being touted by President Joe Biden at his State of the Union address this year.

Some of those who used the drug to treat the virus are reporting an interesting phenomena, though.

The drug, developed by Pfizer, is believed to be highly effective at preventing hospitalization or death in a person that has already been infected with the virus, but some who had their symptoms initially clear up after using the drug are reporting feeling symptoms again later on.

There are multiple reports that a people will also start testing positive for Covid once again after the five day treatment period concludes.

'We had three cases in the house with the same pattern,' John Donoghue, 71, told the Boston Globe.

'The symptoms the second time were milder ... in some ways, we feel that Paxlovid did its job. It took away the extreme symptoms of the first round and reduced them very quickly in all three cases.'

He reported that he, his wife and is mother, 95, all began to take the drug after contracted Covid.

Each started to feel better after using Paxlovid, but and even began to test negative, before their symptoms and positive test status returned once again.

Dr Paul Sax, an infectious disease expert at Brigham and Women's Hospital in Boston, told the Globe he had heard about the same occurring in patients as well.
...
Experts told the Globe that the likely mechanism at play for the Donoghues, and others who have experienced similar phenomena can be described as a game of cat and mouse.

'It's literally that the Paxlovid is the cat, it suppresses the virus, and then when the cat's gone, the mice come out to play,' Dr. Michael Charness, chief of staff at Veterans Affairs Boston told the Globe.

'Paxlovid works really well while it's there, and for many people, they can eliminate the virus in a single phase of infection,'

'But for some people, maybe because it takes a little longer to ramp up immunity, they can't get rid of [all the virus] and the Paxlovid is no longer there to help.'
...
More: https://www.dailymail.co.uk/health/...s-returning-testing-positive-virus-again.html

Interesting. It sounds a bit like not taking enough of an antibiotic. And we know what that leads to: drug resistant strains evolve.

It appears that the immune system, at least in these people, did not get ramped up by the time the drug course was finished.