I love RPG as a genre, but lately they're all kind of the same; mostly dominated by fantasy themes and settings, with hard-to-relate-to characters and plots, not to mention wizards and orcs and s**t.
If there are any programmers among you all, here are three killer ideas for an RPG game that, to my knowledge, NOBODY has done yet.
1. An Old West-themed one, sort of like Red Dead Redemption but with more emphasis on roleplaying, trade, jobs, etc. Classes/careers could include doctors, card sharks, gunslingers, blacksmiths, bounty hunters, and saloon girls, among others.
2. A decent gangster RPG, maybe set during prohibition, where you can establish your own gangs/families, expand your empire through trafficking illegal alcohol, put hits on rival gangsters, etc. Classes could include getaway drivers, explosives experts, enforcers, smugglers, and card sharks, among others.
3. An RPG which takes place in a huge maximum-security prison and really focuses on the prison hierarchy, gaining respect, leveling up your strength by visiting the gym, trading contraband, not getting beaten up, etc. I think this might be the most novel and unique idea of them all.