New sepsis treatment reduces death by 87 percent

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New sepsis treatment reduces death by 87 percent

by: Sharon Thomas

Sepsis, a body-wide infection that can progress to shock and organ failure, features a grim mortality rate of 30 to 50 percent. In fact, one out of every three patients who die in a hospital bed has sepsis – which claims a shocking 270,000 lives in the United States every year.

Now, a new study reveals that a revolutionary vitamin C-based protocol is slashing sepsis mortality rates – causing some to hail it as a ‘miracle.’

Of course, the extraordinary results come as no surprise to high-dose vitamin C pioneers – such as Dr. Thomas E. Levy – who have long advocated for the use of vitamin C in treating disease!

Vitamin C treatment caused mortality rates to plummet
To conduct the retrospective clinical study, researchers compared outcomes of 47 sepsis patients – treated with a combination of intravenous vitamin C, hydrocortisone and thiamine – with 47 sepsis patients treated with conventional medications.

And the results were astounding!

The progressive vitamin C treatment reduced mortality among the sepsis patients by 87 percent (when compared to patients who had been treated with standard therapy.)

Only four of the 47 patients treated with the progressive therapy died – as opposed to 19 of the 47 conventionally-treated patients.

In addition, not one of the patients in the vitamin C group developed organ failure. Furthermore, all of them were able to be weaned off vasopressors (used to ward off dangerous drops in blood pressure that can strike sepsis patients) more quickly than the conventionally-treated group.

Medical professionals deem the mixture a “miracle juice”
The study, which was published in the journal Chest, involved patients at Sentara Norfolk General Hospital in Norfolk, VA.

The patients received the vitamin therapy under the care of Dr. Paul E. Marik. Dr Marik, chief of pulmonary and critical care at Eastern Virginia Medical School, instituted the protocol after reading about intravenous vitamin C in medical journals.

The simple, non-toxic protocol consists of 1.5 grams of intravenous vitamin C every six hours for four days, 200 mg of thiamine – or B1 – every twelve hours for four days, and 50 mg of hydrocortisone every six hours for seven days, followed by a three-day taper.

Over 700 patients in the United States have been treated with Dr. Marik’s protocol to date – at a cost of about $60 per patient.

Compare this to the hundreds of thousands of dollars spent to treat sepsis patients with standard medications!

In an article in The Virginian-Pilot, an ICU nurse at Sentara Norfolk marvels at the treatment results, saying she had witnessed “one patient after another” experiencing remarkable results. “They’d be at death’s door and, 24 to 48 hours later, they had turned around,” she reported.

Is it any wonder that the mixture is commonly referred to by some on the hospital staff as “miracle juice?”

Sepsis is associated with a raised risk of premature death – even years later
Sepsis is usually triggered by a bacterial infection, followed by an extreme over-reaction by the immune system. The inflammatory responses that are unleashed can cause oxidative damage, widespread and abnormal blood clotting, mitochondrial dysfunction and loss of circulation in major organs.

In severe cases, septic shock – in which blood pressure plummets and organs fail – ensues, and may lead to death. Making sepsis even more dangerous is the fact that the debilitating effects persist for months, with over 40 percent of sepsis patients returning to the hospital within 3 months of being discharged.

The somber fact is: even after recovery from sepsis, the risk of dying can remain elevated for years to come.

Red ALERT: Low vitamin C levels are associated with sepsis
Antioxidant and anti-inflammatory, vitamin C seems uniquely qualified to fight sepsis. Vitamin C suppresses inflammation, combats oxidative damage, improves circulation to organs, and boosts the immune system.

Research has also shown that vitamin C and hydrocortisone work together to protect against the capillary leakage that often attends sepsis. Significantly, new evidence has emerged showing that shortfalls in vitamin C can raise the risk of this life-threatening condition.

A 2017 study found that virtually all critically ill sepsis patients had low vitamin C, with 40 percent displaying outright deficiencies. And this was the case despite the fact that the patients were being given dosages of 125 mg of vitamin C per day.

Of course, natural health experts maintain that 125 mg is a woefully inadequate dose – especially for those who are sick. Illness has the effect of depleting vitamin C levels, robbing patients of this important nutrient at a time when they need it most.

Recent research supports the vitamin C protocol
Despite the success rate of intravenous vitamin C, physicians who use it often face a firestorm of criticism from their peers in the mainstream medical community – with some doctors maintaining that the therapy is ‘unproven and ineffective.’

Dr. Marik is philosophical about the negative reaction from the mainstream medical community. “When something is too good to be true, people don’t want to believe it,” he declares.

But, recent peer-reviewed studies and articles are causing some to “change their tune.”

In a 2018 review published in the well-regarded, peer-reviewed Journal of Critical Care, the authors acknowledged that vitamin C could mediate inflammation through its antioxidant activities.

The team reported that emerging evidence supports the administration of vitamin C, in addition to standard therapy, to ease the effects of inflammation and improve blood flow to organs in patients with sepsis and septic shock.

The researchers called for further study to explore the potential of vitamin C therapy. And, they will get their wish.

No less than eight new clinical trials – some using the same three constituents utilized by Dr. Marik – are scheduled to take place in 2018.

As for Dr. Marik, he calls the protocol “safe, cheap and effective.” He also has a more direct way to describe the treatment – “the cure for sepsis.”

Scientific research may just prove him right.

Sources for this article include:

LifeExtension.com
NIH.gov
Pilotonline.com
NaturalHealth365.com
https://www.naturalhealth365.com/sepsis-inflammation-2718.html
 
Wow. Gotta get me some of that. Here, I've been thinking death was pretty much a 100% proposition. Good to know I can get it down to 13% with more vitamin C.
 
It wasn't just vitamin C. They were given hydrocortisone as well. That is actually used already for treating sepsis. https://www.the-hospitalist.org/hos...endocrinology/what-role-steroids-septic-shock Just vitamin C will likely not be enough to help you. Article misleads the reader into thinking it was due to the vitamin C. Vitamin C can help, but that isn't the cure.


The simple, non-toxic protocol consists of 1.5 grams of intravenous vitamin C every six hours for four days, 200 mg of thiamine – or B1 – every twelve hours for four days, and 50 mg of hydrocortisone every six hours for seven days, followed by a three-day taper.

The team reported that emerging evidence supports the administration of vitamin C, in addition to standard therapy, to ease the effects of inflammation and improve blood flow to organs in patients with sepsis and septic shock.
 
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I think Vitamin C (real vitamin C not that ascorbic acid crap) is instrumental in beating/preventing cancer.. I try to eat peppers everyday. And dont get stressed out over shit... stress destroys vitamin C
 
I think Vitamin C (real vitamin C not that ascorbic acid crap) is instrumental in beating/preventing cancer.. I try to eat peppers everyday. And dont get stressed out over $#@!... stress destroys vitamin C

What is "real vitamin C"? How is it different from ascorbic acid?
 
What is "real vitamin C"?


Apparently more real than your fakery in pretending to have a real conversation. You are posting to only be contrary and no other reason. You want to act like some cute smart-ass on here? Then expect the to be treated in kind. Neg rep.

And some research:



1. The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression.
Inflamm. 2017;2017:4024672. doi: 10.1155/2017/4024672. Epub 2017 Jan 22.

"These results suggested that parenteral Vit C has the ability to improve the outcome of sepsis and sepsis-induced MODS and is associated with improvement in cellular immunosuppression."



2. Vitamin C: should we supplement?
Curr Opin Crit Care. 2018 Aug;24(4):248-255.

"A short course of intravenous vitamin C in pharmacological dose seems a promising, well tolerated, and cheap adjuvant therapy to modulate the overwhelming oxidative stress in severe sepsis, trauma, and reperfusion after ischemia."



3. Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?
Crit Care. 2015 Nov 27;19:418. doi: 10.1186/s13054-015-1131-2.

Patients with severe sepsis present with hypovitaminosis C, and pre-clinical and clinical studies have indicated that administration of high-dose ascorbate decreases the levels of pro-inflammatory biomarkers, attenuates organ dysfunction and improves haemodynamic parameters.



And many other studies.
 
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Apparently more real than your fakery in pretending to have a real conversation. You are posting to only be contrary and no other reason. You want to act like some cute smart-ass on here? Then expect the to be treated in kind. Neg rep.

And some research:

Thank you for the links. They looked at vitamin C as a potential adjuvant therapy- one given in additional to regular treatment- not instead of. https://www.medicinenet.com/script/main/art.asp?articlekey=2151

Adjuvant therapy: Treatment that is given in addition to the primary (initial) treatment.

Adjuvant treatment is an addition designed to help reach the ultimate goal. Adjuvant therapy for cancer usually refers to surgery followed by chemo- or radiotherapy to help decrease the risk of the cancer recurring (coming back).

In Latin "adjuvans" means to help and, particularly, to help reach a goal.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661979/

From their conclusion:

Ascorbate-dependent vasopressor synthesis represents a plausible physiological mechanism whereby ascorbate could act as an adjuvant therapy for severe sepsis and septic shock.
 
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What is "real vitamin C"? How is it different from ascorbic acid?

by "real vitamin c" i mean the entire vitamin.. Ascorbic acid is represented as "Vitamin C" but its only part of the vitamin.. without all the parts there is no vitamin activity... Vitamin activity that comes from simple ascorbic acid use is dependent on the body having stores of the other parts of the vitamin at best and at worst wont work at all.. so just to be safe id eat a whole food like peppers to ensure proper vitamin activity.
 
by "real vitamin c" i mean the entire vitamin.. Ascorbic acid is represented as "Vitamin C" but its only part of the vitamin.. without all the parts there is no vitamin activity... Vitamin activity that comes from simple ascorbic acid use is dependent on the body having stores of the other parts of the vitamin at best and at worst wont work at all.. so just to be safe id eat a whole food like peppers to ensure proper vitamin activity.

What are the "other parts"? True some vitamins work better in concert with other vitamins and minerals. That does not make the vitamin "fake".

dependent on the body having stores of the other parts of the vitamin at best

Vitamin C is water soluble. The body does not store it.
 
Thank you for the links.


Why are you being sugary disingenuous, especially when your purpose here is a nasty thwarting of this site? Oh, I know why. It's just part of your little game playing.

They looked at vitamin C as a potential adjuvant therapy-

LOL. No, they did not. You are purposely being obtuse or just now downright lying. Neg rep.
 
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What are the "other parts"? True some vitamins work better in concert with other vitamins and minerals. That does not make the vitamin "fake".




Vitamin C is water soluble. The body does not store it.

one of the other parts is the mineral copper.. so without copper there wont be any Vitamin C activity.
 
Why are you being sugary disingenuous, especially when your purpose here is a nasty thwarting of this site? Oh, I know why. It's just part of your little game playing.



LOL. No, they did not. You are purposely being obtuse or just now downright lying. Neg rep.

I simply quoted from your source. If you disagree with that...
 
Vitamin C supplementation in the critically ill patient.
Curr Opin Clin Nutr Metab Care. 2015 Mar;18(2):193-201

"Clinical trials in sepsis, trauma and major burns testing high-dose vitamin C show clinical benefit. Restoration of normal plasma levels in inflammatory patients requires the administration of 3 g/day for several days, which is 30 times the daily recommended dose."



Resolution of sterile inflammation: role for vitamin C.
Mediators Inflamm. 2014;2014:173403. doi: 10.1155/2014/173403. Epub 2014 Sep 9.

"Parenteral vitamin C (VitC) attenuates proinflammatory states in murine and human sepsis."

***

"VitC sufficiency and in vivo VitC supplementation restored macrophage phenotype and function."



Vitamin C revisited.
Crit Care. 2014 Aug 6;18(4):460. doi: 10.1186/s13054-014-0460-x.


"Preclinical studies show that high-dose vitamin C can prevent or restore microcirculatory flow impairment by inhibiting activation of nicotinamide adenine dinucleotide phosphate-oxidase and inducible nitric oxide synthase, augmenting tetrahydrobiopterin, preventing uncoupling of oxidative phosphorylation, and decreasing the formation of superoxide and peroxynitrite, and by directly scavenging superoxide. Vitamin C can additionally restore vascular responsiveness to vasoconstrictors, preserve endothelial barrier by maintaining cyclic guanylate phosphatase and occludin phosphorylation and preventing apoptosis. Finally, high-dose vitamin C can augment antibacterial defense. These protective effects against overwhelming oxidative stress due to ischemia/reperfusion, sepsis or burn seems to mitigate organ injury and dysfunction,..."


..
 
one of the other parts is the mineral copper.. so without copper there wont be any Vitamin C activity.

Copper competes with vitamin C in the intestines (even though it uses them both differently). If you are taking a lot of vitamin C you may be reducing the amount of copper in your body. That is why you need more copper with it.

https://www.lifeextension.com/Magazine/2000/9/report_copper/Page-01

Ascorbic acid (vitamin C) has been found to antagonize the absorption of copper intestinally, and can impede the binding of copper to copper-zinc superoxide dismutase (Cu,Zn)SOD.5

A 1988 study from the Department of Foods and Nutrition at the University of Georgia also found that after feeding male rats various amounts of copper, iron and vitamin C for 20 days, high intakes of iron and/or vitamin C dramatically reduced copper levels. Results showed that high iron intake decreased copper absorption in copper-deficient rats, high vitamin C intake significantly decreased tissue copper levels in rats with adequate copper intake, and high iron plus high vitamin C caused severe anemia in copper-deficient rats, while dropping ceruloplasmin levels in copper-adequate rats by 44%.8
 
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Copper competes with vitamin C (even though it uses them both differently). If you are taking a lot of vitamin C Ascorbic Acid you may be reducing the amount of copper in your body. That is why you need more copper with it.

https://www.lifeextension.com/Magazine/2000/9/report_copper/Page-01
Do you understand what Im saying? Copper is part of the whole vitamin c.. When you take ascorbic acid your body is going to need copper to facilitate vitamin activity, because copper is part of the vitamin.
 
Do you understand what Im saying? Copper is part of the whole vitamin c.. When you take ascorbic acid your body is going to need copper to facilitate vitamin activity, because copper is part of the vitamin.

Link? Copper is a mineral- not a vitamin.
 
Link? Copper is a mineral- not a vitamin.

Let me explain it as clearly as I can.

There is a reason why vitamins in food are useful in healing and vitamins in synthetic pills arent as useful.. And the reason is because the vitamin in its natural whole state only exists in the food and not in the synthetic pill... As an example we can point to the discoverer of Vitamin C who said that he was never able to curve scurvy with the synthetic vitamin but could do so easily with peppers. (he was from the area of Hungary that was known for producing paprika from peppers)

Doctors will admit to synthetic Vitamin E as being much less effective than natural Vitamin E but for some reason stop the discussion at Vitamin E.

But to summarize we can say that ascorbic acid is not vitamin c, retinoic acid is not vitamin a, alpha tocopherol is not vitamin e, etc etc etc.

Vitamin C as a vitamin is made of many components other than ascorbic acid, there are enzymes and co-enzymes, bioflavonoids, not to mention the mineral copper. the mineral copper is PART of Vitamin C, just like cobalt is part of Vitamin B-12.
 
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