Ibuprofen Kills Thousands Each Year, So What Is The Alternative?

donnay

Member
Joined
Nov 20, 2007
Messages
42,534
Ibuprofen Kills Thousands Each Year, So What Is The Alternative?

8th September 2015
By Sayer Ji

A recent Reuters’ article opened with the following stunning sentence:

“Long-term high-dose use of painkillers such as ibuprofen or diclofenac is ‘equally hazardous’ in terms of heart attack risk as use of the drug Vioxx, which was withdrawn due to its potential dangers, researchers said.”

The 2004 Vioxx recall, as you may remember, was spurred by the nearly 30,000 excess cases of heart attacks and sudden cardiac deaths caused by the drug between 1999-2003. Despite the fact that scientific research had accumulated as early as 2000 linking Vioxx to increased heart attacks and strokes, the drug’s manufacturer Merck, and the FDA, remained silent as the death toll steadily increased.

The Reuters report focused on new research published in Lancet indicating the risk of heart attack increases as much as a third and the risk of heart failure doubles among heavier users of NSAID drugs.

Why are so many folks taking NSAID drugs like ibuprofen anyway?

Pain and unhealthy levels of inflammation are fast becoming default bodily states in the industrialized world. While in most cases we can adjust the underlying pro-inflammatory conditions by altering our diet, and reducing stress and environmental chemical exposures, these approaches take time, discipline and energy, and sometimes we just want the pain to stop now. In those often compulsive moments we find ourselves popping an over-the-counter pill to kill the pain.

The problem with this approach is that, if we do it often enough, we may kill ourselves along with the pain…

Continued...
 
Article says risk is to people taking very high doses over long periods of time. Not average people.

http://www.reuters.com/article/2013...S1FV20130529?feedType=RSS&feedName=healthNews

He stressed that the risks are mainly relevant to people who suffer chronic pain, such as patients with arthritis who need to take high doses of painkillers - such as 150mg of diclofenac or 2400mg of ibuprofen a day - for long periods.

"A short course of lower dose tablets purchased without a prescription, for example, for a muscle sprain, is not likely to be hazardous," he said.

and among that small group of people,

This means that for every 1,000 people with an average risk of heart disease who take high-dose diclofenac or ibuprofen for a year, about three extra would have an avoidable heart attack, of which one would be fatal, the researchers said.

"Killing thousands" is an exaggeration.
 
Last edited:
"Killing thousands" is an exaggeration.
Thank you!

It's nice to have someone finally speaking sense in the sea of sensationalism.

So just to be clear, how many people, precisely, die from Ibuprofen attributed deaths annually?

I feel the issue might be misrepresented if this figure is not specifically scientific and known.
 
FDA Drug Safety Communication: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes
http://www.fda.gov/Drugs/DrugSafety/ucm451800.htm

NSAIDs and the Risk of Heart Problems and Stroke
http://www.arthritis.org/living-wit...es/nsaids/nsaids-heart-attack-stroke-risk.php

High-Dose NSAIDs Hike Risk of Heart Attack
http://www.medpagetoday.com/PainManagement/PainManagement/39457

Diclofenac Causes as Many Heart Attacks as Vioxx
http://articles.mercola.com/sites/articles/archive/2013/02/27/diclofenac-dangers.aspx

Nonsteroidal anti-inflammatory drugs and heart failure.
http://www.ncbi.nlm.nih.gov/pubmed/12656651

Cardiovascular risks of nonsteroidal antiinflammatory drugs in patients after hospitalization for serious coronary heart disease.
http://www.ncbi.nlm.nih.gov/pubmed/20031832

NSAIDs and Cardiovascular Risk Explained, According to Studies from the Perelman School of Medicine
http://www.uphs.upenn.edu/news/news_releases/2012/05/risk/

How Big Pharma Cooks Data: The Case of Vioxx and Heart Disease
http://mathbabe.org/2012/02/15/how-big-pharma-cooks-data-the-case-of-vioxx-and-heart-disease/
 
Why are people taking so much ibuprofen? Because the less toxic stuff that actually works is illegal or available by prescription only. I'd sure as hell rather take a single vicodin when I get a migraine than 800mg of Ibu. I'll probably die 20 years earlier than I should because of the narcotic drug war idiocy.
 
The article said you can fix inflammation by "simply altering your diet"?

While Vioxx is an NSAID, you can't compare it with other NSAIDs without talking about things like the COX level, as well as selective and non-selective meds. To compare Motrin to Vioxx is a very dumbed down argument. That article linked in the OP is written by a complete moron. They make it out like Merk was allowing people to die, and keeping quiet about it. That is not at all what happened. When they started to see reports of some increased risks, Merk ran their own studies. When they saw some risk in the volunteers, they immediately stopped the studies, and recalled the drug on their own. The FDA ran their own studies, and while risk was found, saw no need for a recall. Merk wasn't hiding in the shadows counting money, and letting people die.

If you notice as well, they talk about mixing drugs leading to fatal ends. Well, no shit. I've lost two siblings to mixing meds, but in no world was I a pompous enough ass to want to blame the drug companies.

I know there are links that PROVE motrin is a deadly killer, but those same links also say things like the earth is flat, and Elvis is still alive. I encourage people to read and learn, but like it or not, sooner or later we have to accept some things need understanding before diving in.
 
800 mg is the recommended ibuprofen dose. The increased risks in the study kicked in at 2400 mg a day every day for at least a year. 3200 mg is the maximum daily dose.
 
Last edited:
The article said you can fix inflammation by "simply altering your diet"?

While Vioxx is an NSAID, you can't compare it with other NSAIDs without talking about things like the COX level, as well as selective and non-selective meds. To compare Motrin to Vioxx is a very dumbed down argument. That article linked in the OP is written by a complete moron. They make it out like Merk was allowing people to die, and keeping quiet about it. That is not at all what happened. When they started to see reports of some increased risks, Merk ran their own studies. When they saw some risk in the volunteers, they immediately stopped the studies, and recalled the drug on their own. The FDA ran their own studies, and while risk was found, saw no need for a recall. Merk wasn't hiding in the shadows counting money, and letting people die.

If you notice as well, they talk about mixing drugs leading to fatal ends. Well, no shit. I've lost two siblings to mixing meds, but in no world was I a pompous enough ass to want to blame the drug companies.

I know there are links that PROVE motrin is a deadly killer, but those same links also say things like the earth is flat, and Elvis is still alive. I encourage people to read and learn, but like it or not, sooner or later we have to accept some things need understanding before diving in.

How Big Pharma Cooks Data: The Case of Vioxx and Heart Disease
http://mathbabe.org/2012/02/15/how-b...heart-disease/

Merck published fake journal
http://www.the-scientist.com/?articles.view/articleNo/27376/title/Merck-published-fake-journal/

When clinical trials are designed by the marketing department
http://scienceblogs.com/insolence/2008/08/21/when-clinical-trials-are-designed-by-marketing/
 
Of course. So in essence, you argument is that Merk faked data, falsified reports, and went public all so they could do the devious thing of voluntarily pulling the number one prescribed NSAID, when the FDA just wanted them to annotate the POSSIBLE risk with the drug.

Those devious bastards....

You have your links, but I have my wife, who is a healthcare provider, as well as my own experience. I'll take our combined experience, as well as her master's degree in medicine over some link that fabricates history on it's way to trying to talk abut pharmaceutical chemistry as a toddler might approach basic math.
 

Does that mean that the study saying NSAIDs kill people is also false and they are actually GOOD for you? We should take them with every meal then.

Or are only SELECT studies which don't fit your perceptions faked?
 
Why are people taking so much ibuprofen? Because the less toxic stuff that actually works is illegal or available by prescription only. I'd sure as hell rather take a single vicodin when I get a migraine than 800mg of Ibu. I'll probably die 20 years earlier than I should because of the narcotic drug war idiocy.

I have bad knees, a shoulder, and have major surgery on my back last October (had to remove a disc and part of a vertebrae). I tried to avoid the surgery, but that ended when my wife found me on the floor unable to walk and terrified. I was very depressed when they started talking about pain management clinics, as my metabolism inherited from the family makes me very resistant to booze, narcotics, hell....laughing gas has zero effect on me. In other words, the thought of having bottles of oxycontin, hydromorphone, fentnyl, ect part of my daily routine reinforced to me what I was already thinking, in that I was going to spend the rest of my life a cripple.

Granted, I have hydrocodone for bad days, but my doctor said I should give mobic / meloxicam a chance. It is a NSAID, labled under both COX-1 /COX-2. It's a 15mg pill a day, takes a few days before you start to notice anything, but they work. Well, for me at least. My wife has migraines as well, and she said, "Tell him if he doesn't have Relpax, to go tell his doc to get that script wrote ASAP." Her's are horrible, and she manages them very well with that med. Only once in a blue moon is it so bad for her that she goes into my mdicine cabinet, because Relpax failed her. And this, "Be sure he knows narcotics can cause more intense rebound pain with a migraine, and should be his last act for relief."
 
I have bad knees, a shoulder, and have major surgery on my back last October (had to remove a disc and part of a vertebrae). I tried to avoid the surgery, but that ended when my wife found me on the floor unable to walk and terrified. I was very depressed when they started talking about pain management clinics, as my metabolism inherited from the family makes me very resistant to booze, narcotics, hell....laughing gas has zero effect on me. In other words, the thought of having bottles of oxycontin, hydromorphone, fentnyl, ect part of my daily routine reinforced to me what I was already thinking, in that I was going to spend the rest of my life a cripple.

Granted, I have hydrocodone for bad days, but my doctor said I should give mobic / meloxicam a chance. It is a NSAID, labled under both COX-1 /COX-2. It's a 15mg pill a day, takes a few days before you start to notice anything, but they work. Well, for me at least. My wife has migraines as well, and she said, "Tell him if he doesn't have Relpax, to go tell his doc to get that script wrote ASAP." Her's are horrible, and she manages them very well with that med. Only once in a blue moon is it so bad for her that she goes into my mdicine cabinet, because Relpax failed her. And this, "Be sure he knows narcotics can cause more intense rebound pain with a migraine, and should be his last act for relief."

If I could afford to see a doctor I wouldn't be using IB for migraines. :p and yeah, they get really, really bad. like buried in my room completely debilitated, unable to move and vomiting. when they get really REALLY bad I'll take 1400mg IB, which sucks, because it causes internal bleeding.
 
If I could afford to see a doctor I wouldn't be using IB for migraines. :p and yeah, they get really, really bad. like buried in my room completely debilitated, unable to move and vomiting. when they get really REALLY bad I'll take 1400mg IB, which sucks, because it causes internal bleeding.

Have you ever tried raw ginger? Chewing on it helps relieve the pain and helps the upset stomach.

Magnesium glycinate is also good to take daily to help prevent migraines.

Also Turmeric is excellent pain reliever and anti-inflammatory.
 
For me, I am chewing raw Garlic whenever I have something inflammed. It actually helps and it works right away! Also helps lower your blood pressure.
 
If I could afford to see a doctor I wouldn't be using IB for migraines. :p and yeah, they get really, really bad. like buried in my room completely debilitated, unable to move and vomiting. when they get really REALLY bad I'll take 1400mg IB, which sucks, because it causes internal bleeding.

My condolences. Dh used to get them quite frequently when he was a printer. I told him it was likely the chemicals he huffed every day that he was addicted to as the headaches came every time he was not working. He hasn't had a horrible headache like you described in quite some time and the relief seems to have coincided with his leaving the print industry. I never realized how horrible headaches could be until I saw him suffer so much.
 
If I could afford to see a doctor I wouldn't be using IB for migraines. :p and yeah, they get really, really bad. like buried in my room completely debilitated, unable to move and vomiting. when they get really REALLY bad I'll take 1400mg IB, which sucks, because it causes internal bleeding.

Gunny, you are a "Vet." V.A., duh. WTF man? I've have been prescribed bi-focals incoming. Why are you not requiring the the company that promised you benefits to live up to their end of the agreement?
 
Back
Top