gofundme for Shem's cancer

Mad Raven said:
Just a suggestion, but the more of your story you can share, the more people will donate.

Personally I believe chemo is a scam, and I can't support that decision. Chemo makes you feel horrible, wrecks your body permanently, and doesn't do a thing to cure cancer. The small number of people (2% or so) whose cancer reduces or disappears during chemo are also the same people who would have gotten better without it, and do.

Some alternative treatments at least can't really hurt. The people who cure cancer do it with the power of their mind.
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Thanks the gofundme is brand new. My story is in the facebook group.

I too believe chemo is a scam. I know from experience that is is making me feel horrible and is wrecking my body permanently.

I hope that some alternatives that can't really hurt will actually help. I am trying some now and hope to try more.

I'm not speaking from experience here, maybe you are, but i think to say that people who cure cancer do it with the power of their mind is an oversimplification. I think that there are alternative treatments that can and have helped beat cancer.
 
Just donated $50. Cancer is such a scourge....

When I was 6 years old, my father was terminal with non-Hodgkin's lymphoma; likely from exposure to agent orange in Vietnam. He was on chemo but the doctors gave him 6 months to live. He eventually relied entirely on God by praying and reading the Word everyday and trusting entirely in Him. Several months later, the cancer was completely gone and the doctors were baffled. It's hasn't come back since and that was over 25 years ago.

I'm not saying this to recommend you stop chemo, just to give you hope. You are in my prayers.
 
:) Thanks to all who joined. Nice to be a part of the first successful match string. Hope we see more...

ShemMatchString_zpsxcn9zyb8.png
 
Shem has revised the goal of this, and posted the update quoted below:

Let's CURE Shem.

After launching this gofundme, we had a friend share my plea to his Facebook wall. A non-mutal friend commented on the post. She said she had a friend of a friend who was about my age who also diagnosed with my same cancer who was also told he'd recieve chemotherapy for the rest of his life. This friend of a friend felt that the chemotherapy was killing him and he sought out and ultimately received alternative non FDA approved treatment outside of the States. His cancer was supposedly gone after six weeks.

Through the wonders of Facebook we were able to track down the patient. On Sunday Carla and I spoke with patient Jonathan and his wife and care giver Tyler. Sure enough, he confirmed the story. He spent 3 weeks at the Hope for Cancer facility in Mexico and left with a three-month supply of meds. He was clear of cancer in 6 weeks. This weekend he had his colostomy surgery reversed. He is a survivor. Carla and I were ecstatic.

Hope for Cancer's core treatment is PNC-27, which is a peptide and is injected intravenously that binds only to cells with tumor markers and kills them. The PNC-27 therapy is complimented by Rigvir virotherapy. Rigvir, a virus, which unable to replicate in the human body and that only goes after cancer cells. These treatments are supplemented by a number of alternative support therapies like Vitamin C infusions, coffee enemas, B17 (apricot seeds), etc. The treatment includes an educational "classroom" component; topics include nutrition and spiritual and emotional integrity. Hope for Cancer prepares you to live the rest of your life.

Some testimonials: https://vimeopro.com/user19574245/testimonials

At the moment, I am unwilling to accept conventional American medicine's recommended treatment of chemotherapy for the rest of my life.

While I am still strong I'd like to pursue a cure. Please help me raise the funds I need to pay for it. The fundraising goal includes airfare, room and board and transportation and treatment for three weeks, and the three month supply of meds.

If this update moves you to donate again and you can afford to do so that's awesome. I hope that it at least moves you to share the gofundme page one more time.

Love,

Shem
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https://www.gofundme.com/egpardt8
 
Shem, have you already started taking the B-17/apricot pits? I had thought of sending you a pack, but I see it's on your new regimen. Sent in a small donation, hope it helps.
 
Kotin said:
this drug actually looks good from a medicinal chemistry point of view.. I have seen several similar peptide drugs for other diseases.. while they have to be injected due to poor oral bio availability, that is the only downside for the most part. looks promising
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And THAT ^^^ is good to hear from a personally trusted source. Thanks for taking an educated look
 
ronpaulhawaii said:
And THAT ^^^ is good to hear from a personally trusted source. Thanks for taking an educated look
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not a problem!

selective toxicity is the way to kill most things meaning that we use something that is toxic to the pathogen or cancer but not to healthy cells

so this drug is a engineered protein which has a special domain(functional chain of amino acids) which specifically binds to a cell surface structure which is only expressed by cancer cells and not healthy cells and so it binds to this structure and causes perforation(holes) and subsequent cancer cell necrosis but leaves healthy cells intact.

the benefits of peptide drugs outweigh any oral bio availability problems especially because they are injected which mitigates that problem effectively. these benefits include the fact that many small molecule drugs have metabolites which can be toxic after they pass through the liver oxidation while peptide drugs are metabolized into harmless and essential amino acids like when we eat a protein so much lower or almost no chance of toxic metabolites. these also have much less interactions with other drug targets since they are less likely to have a structure similar to our own bodily small molecule hormones and signaling molecules.

seems like the only reason its not FDA approved is because its an incredibly expensive process as well as the industry is bias against treatments that actually work in my opinion.

please keep us updated shem!!
 
I'm trying to raise funds via ebay for an MRI for my son. I'll try to donate a % of what I make toward this when I've sold some more.
 
Kotin said:
this drug actually looks good from a medicinal chemistry point of view.. I have seen several similar peptide drugs for other diseases.. while they have to be injected due to poor oral bio availability, that is the only downside for the most part. looks promising
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Definitely looks promising.



Ann Clin Lab Sci. 2014 Summer;44(3):241-8.
The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells.
Davitt K1, Babcock BD1, Fenelus M2, Poon CK2, Sarkar A2, Trivigno V2, Zolkind PA2, Matthew SM2, Grin'kina N3, Orynbayeva Z1, Shaikh MF1, Adler V1, Michl J4, Sarafraz-Yazdi E5, Pincus MR6, Bowne WB7.
Author information

1Department of Surgery, Drexel University College of Medicine, Philadelphia, PA.
2Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY.
3Division of Pharmacology and Physiology, Department of Microbiology and Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY.
4Department of Pathology, SUNY Downstate Medical Center, Brooklyn, NY Department of Microbiology and Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY.
5Department of Pathology, SUNY Downstate Medical Center, Brooklyn, NY.
6Department of Pathology, SUNY Downstate Medical Center, Brooklyn, NY Department of Pathology and Laboratory Medicine, New York Harbor VA Medical Center, Brooklyn, NY and New York, NY, USA.
7Department of Surgery, Drexel University College of Medicine, Philadelphia, PA Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY [email protected] [email protected].

Abstract
GOALS:

We have developed the anti-cancer peptide, PNC-27, which is a membrane-active peptide that binds to the HDM-2 protein expressed in the cancer cell membranes of solid tissue tumor cells and induces transmembrane pore formation in cancer, but not in normal cells, resulting in tumor cell necrosis that is independent of p53 activity in these cells. We now extend our study to non-solid tissue tumor cells, in this case, a primitive, possible stem cell human leukemia cell line (K562) that is also p53-homozygously deleted. Our purpose was twofold: to investigate if these cells likewise express HDM-2 in their plasma membranes and to determine if our anti-cancer peptide induces tumor cell necrosis in these non-solid tissue tumor cells in a manner that depends on the interaction between the peptide and membrane-bound HDM-2.
PROCEDURES:

The anti-cancer activity and mechanism of PNC-27, which carries a p53 aa12-26-leader sequence connected on its carboxyl terminal end to a trans-membrane-penetrating sequence or membrane residency peptide (MRP), was studied against p53-null K562 leukemia cells. Murine leukocytes were used as a non-cancer cell control. Necrosis was determined by measuring the lactate dehydrogenase (LDH) release and apoptosis was determined by the detection of Caspases 3 and 7. Membrane colocalization of PNC-27 with HDM-2 was analyzed microscopically using fluorescently labeled antibodies against HDM-2 and PNC-27 peptides.
RESULTS:

We found that K562 cells strongly express HDM-2 protein in their membranes and that PNC-27 co-localizes with this protein in the membranes of these cells. PNC-27, but not the negative control peptide PNC-29, is selectively cytotoxic to K562 cells, inducing nearly 100 percent cell killing with LDH release. In contrast, this peptide had no effect on the lymphocyte control cells.
CONCLUSIONS:

The results suggest that HDM-2 is expressed in the membranes of non-solid tissue tumor cells in addition to the membranes of solid tissue tumor cells. Since K-562 cells appear to be in the stem cell family, the results suggest that early developing tumor cells also express HDM-2 protein in their membranes. Since PNC-27 induces necrosis of K-562 leukemia cells and co-localizes with HDM-2 in the tumor cell membrane as an early event, we conclude that the association of PNC-27 with HDM-2 in the cancer cell membrane results in trans-membrane pore formation which results in cancer cell death, as previously discovered in a number of different solid tissue tumor cells. Since K562 cells lack p53 expression, these effects of PNC-27 on this leukemia cell line occur by a p53-independent pathway.

© 2014 by the Association of Clinical Scientists, Inc.
...
https://www.ncbi.nlm.nih.gov/pubmed/25117093
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