lol - I never want to say never, but it would take a DRAMATIC shift in the way things work.
The lobbyists hate him. His fundraising would be from low dollar supporters, but he'd be up against behemoths. He can do it in a small district where they know him, but it won't work nationally.
I get the sense that Massie has no interest in ever running for POTUS. He knows it would be a waste of time. He would also need an endorsement of Trump and we know that's not going to happen.