Nearly all of the questions to Ron Paul were on controversial issues where he's known to be an outlier. They went out of their way to highlight points on which Republican voters are likely to disagree with him.
This. My mom is a huge social conservative and fundamentalist who believes the government has the power at the federal level to dictate morality. Okay, so maybe not that extreme, but while Ron can say, "I'm personally against such-and-such and using drugs, etc., I don't think the government can stop people," my mom would say, "While the government can't stop people, it would be morally unthinkable if it didn't even try!" Ron Paul lost a lot of points with her during this debate and she voted for him last year. Tim Pawlenty also lost points with her because he thought it should be up to the local schools, the community, and the parents to decide whether creationism should be taught.