Inexpensive steroid dexamethasone is the first drug to reduce deaths from covid-19

[Brian4Liberty]

Inexpensive steroid dexamethasone is the first drug to reduce deaths from covid-19

LONDON — An inexpensive steroid reduced deaths from coronavirus infection, helping some of the sickest patients with severe lung damage survive the illness, according to British clinical trial results announced Tuesday in a news release.

The 60-year-old drug, dexamethasone, is the first medication shown to increase people’s chances of surviving covid-19, the disease caused by the novel coronavirus. It reduced the risk of death for patients on ventilators by a third and cut the risk of death for patients on oxygen by a fifth, heartening news that drew widespread interest and hope.

British regulators speedily approved the drug for use in hospitalized patients requiring oxygen, and Prime Minister Boris Johnson trumpeted the results, declaring there was “genuine cause to celebrate a remarkable British scientific achievement and the benefits it will bring not just in this country but around the world.”
...
Dexamethasone is a workhorse steroid typically used to treat inflammation, including flare-ups of rheumatoid arthritis, and was given as a tablet, liquid or as an intravenous preparation in the trial. Some other steroids are also being tested against covid-19.
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As of Tuesday afternoon, treatment guidelines from the World Health Organization and the National Institutes of Health recommended against using steroids because of the lack of evidence that the benefit of the drugs outweighs potential harm.

Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases, said in an interview Tuesday that a group of experts who craft guidelines on treating covid-19 is already planning to meet to evaluate the data and assess whether recommendations should be changed.
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More: https://www.washingtonpost.com/heal...thasone-is-first-drug-reduce-deaths-covid-19/

 

[Brian4Liberty]

Trump better keep his mouth shut on this. If he says anything positive, that will be an excuse for Fauci and the pharma-media complex to attack it.

And everyone else will immediately takes sides.

 

[Warrior_of_Freedom]

Trump better keep his mouth shut on this. If he says anything positive, that will be an excuse for Fauci and the pharma-media complex to attack it.

And everyone else will immediately takes sides.

I thought Trump told us all to inject bleach into our veins!

 

[LibertyEagle]

Steroids are a major no-no, if you've had Lyme Disease.

 

[KrokHead]

Like anything corona related (whether it mutates, how to prevent it, where it came from, etc.) It will be contradicted within a week. All I know is I wouldn't want to be a lab rat if I caught covid-19.

 

[Swordsmyth]

Amazing study finds miracle cure for Coronavirus – Dexamethasone. Notice, they claim hydroxychloroquine will kill more patients than would die without it, but Dex will save everyone. It is not impossible if the doses are small enough, since Dex will crush inflammation – but then why not use Prednisone, which is weaker and would allow a precise dose. I am struck by early reports Ibuprofen was killing people by shutting off a critical immune component and letting the virus go wild unimpeded. Dexamethasone is a stress-steroid, whose biological function is to turn off all non-critical processes, so the body can devote all energy to fundamental life-sustaining biochemical processes, making it through a stress – and that means it also shuts off the immune system, which is considered non-essential for immediate, minute to minute survival. You can think of it like this – if you have to run from a Saber Toothed Tiger, and you have the flu, you will release cortisol (the incredibly weak, natural form of dexamethasone (see a chart here comparing the strength and duration of action of various corticosteroids relative to Cortisone which is essentially the same as Cortisol). That Cortisol will shut off your immune response to the flu. You will feel healthy, and run fast, but inside your body the virus is advancing as if you have no immune system. It is the best way – because if the immune system was left on, you would feel sick, run slow, and end up eaten. After you escape, the idea is the stress steroid goes away, and you have to play catch-up against the virus, but you are still alive to do so. That is what a stress-steroid does. So you can understand my skepticism that our health care workers are now being told to give Coronavirus patients Dexamethasone, which is only about 30 times as potent as Cortisol at shutting down the immune system, and lasts 4 times as long. If this is sabotage, they are looking for a way to supercharge the virus to increase damage, and they are looking to trick healthcare workers into administering a bad treatment that shuts off the immune system to make it happen. It is actually quite perfect, to the point I am a bit disappointed I didn’t sit down a couple of weeks back, look at what they’d need to improve the effectiveness of the virus, realize they’d need to weaken people, and see this coming, based on the hydroxychloroquine study. But I suppose I’d have thought doctors would be too smart for it, and I’d have disregarded the possibility. Don’t trust anything, because anything you see may be actual disinformation these days.

https://www.anonymousconservative.com/blog/news-briefs-06-17-2020/#comment-344924

 

[dannno]

https://www.anonymousconservative.com/blog/news-briefs-06-17-2020/#comment-344924

Dammit, they just won't quit.

Time for arrests, this is bullshit.

 

[Dr.3D]

https://www.anonymousconservative.com/blog/news-briefs-06-17-2020/#comment-344924

Maybe it's about slowing the immune response to keep from having cytokine storm syndrome. Seems that causes so much inflammation in the lungs, people can't breath.

 

[Brian4Liberty]

Maybe it's about slowing the immune response to keep from having cytokine storm syndrome. Seems that causes so much inflammation in the lungs, people can't breath.

Beat me to it.

+rep

 

[Anti Globalist]

FDA will now make sure that nobody can get this on the market.

 

[navy-vet]

Maybe it's about slowing the immune response to keep from having cytokine storm syndrome. Seems that causes so much inflammation in the lungs, people can't breath.

That's exactly what I thought too, when I read about this the other day doc.

 

[Swordsmyth]

Maybe it's about slowing the immune response to keep from having cytokine storm syndrome. Seems that causes so much inflammation in the lungs, people can't breath.

That's the idea but AC is suggesting that there is at least one better option that is less likely to go too far and let the virus run wild while the immune system is suppressed.

 

[navy-vet]

[FONT=&quot]Sometimes the body’s response to infection can go into overdrive. For example, when SARS -CoV-2 – the virus behind the [/FONT]covid-19 pandemic[FONT=&quot] – enters the lungs, it triggers [/FONT]an immune response[FONT=&quot], attracting immune cells to the region to attack the virus, resulting in localised inflammation. But in some patients, excessive or uncontrolled levels of cytokines are released which then activate more immune cells, resulting in hyperinflammation. This can seriously harm or even kill the patient.[/FONT][FONT=&quot]

Read more: https://www.newscientist.com/term/cytokine-storm/#ixzz6Ppx8e2H1[/FONT]

 

[navy-vet]

This is one explanantion that I found as being the most informative:

 

[Danke]

This is one explanantion that I found as being the most informative:

March 23, 3 months later this has proven to be BS.

 

[navy-vet]

March 23, 3 months later this has proven to be BS.

yes, I believe that I posted it myself, back then. How is it BS?

 

[navy-vet]

I have seen ARD take a life, with my own eyes. I was a health practioner, educator, and clinician for thirty years. I find this explanation plausible. Why do you call it BS?

 

[navy-vet]

As for the dire predictions that failed to materialize, I could argue that the actions taken through isolation alone could have effected those numbers. And no one, can predict the mutaion rate as it progresses through a population. Especially with a novel virus like this one. I believe that it has (the pandemic) and is, being distorted, exagerated, to further special interests though. Which is a different thing from what I am talking about here. But as to the kinematics and physiology, this guy is spot on , IMO. I have a scientific mind and am open to changing it if you have some information I have missed.

 

[seapilot]

I have seen ARD take a life, with my own eyes. I was a health practioner, educator, and clinician for thirty years. I find this explanation plausible. Why do you call it BS?

It has been shown it does not directly attack the lungs. It enters through the lungs into the circulatory system. It attacks the endothelial , creating blood clots causing organ failure.

 

[dannno]

It has been shown it does not directly attack the lungs. It enters through the lungs into the circulatory system. It attacks the endothelial , creating blood clots causing organ failure.

I am also under the impression that free radicals attack the lungs, which is one reason why vitamin C is a pretty good treatment as well.