First case of China-linked coronavirus reported in US

Fwiw, neither of the Chinese manufacturers I do business with are producing anything right now, even though the Chinese new year is over. One, who is a large manufacturer of mechanical machinery, hasn't replied to any of my inquiries (very unusual) and the other is replying but says she is working from home instead of in the office and the streets are empty. Production has not restarted. She originally said production was to be restarted Feb 8 but has walked that back since. Her factory is about 7hrs drive away from Wuhan in Changzhou.
 
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[h=4]Corona Virus Spreads into Iran, as Khomeinist Regime Safeguards Trade with Their Chinese Masters[/h] As the Corona virus spreads from China around the world, Iranians are incensed that the Khomeinist regime is not doing enough to protect them from the disease. The regime’s Ministry of Health claims that no cases of the virus have been detected in Iran, but that two tourists, one Chinese and one German, are being quarantined in Yazd after displaying possible symptoms.


However, video clips were diffused on social media claiming to show cases of the virus in Kordestan and Hormozgan provinces. Two men were arrested on charges of “spreading fake news” for posting these videos, but in the context of a notoriously lying regime, the veracity or falsehood of these claims is still unclear.


Despite multiple airlines around the world temporarily suspending flights to and from areas affected by the virus in China, the Islamic Revolutionary Guards Corps (IRGC)-tied Mahan Airways is still continuing Chinese trips, including to and from Wuhan, where the outbreak first erupted. Regime officials, including foreign minister Mohammad Javad Zarif, have publicy stated messages of support for China, leading many Iranians to feel that the regime cares more about preserving their trade and arms deals with China, instead of being concerned about the lives of the Iranian people. Iranians have also reported that it is nearly impossible find protective face masks in the country, because the expatriate Chinese in Iran have requisitioned Iran’s whole supply of masks for themselves.

More at: https://www.thegatewaypundit.com/20...-safeguards-trade-with-their-chinese-masters/
 
The virus doesn't just infect Asians. It just started in an Asian country.

Asian males have 5 times as many cells that are vulnerable to this virus and whites have an enzyme that mitigates it:

https://twitter.com/Perpetualmaniac/status/1224749841797926912 According to Chinese scientists, the Corona Virus attaches onto lung receptors that are five times more likely in Asian males:
https://biorxiv.org/content/10.1101/2020.01.26.919985v1.full
Also... white people are essentially immune because we have the acetylcholinase inhibitor against the virus.
 
Asian males have 5 times as many cells that are vulnerable to this virus and whites have an enzyme that mitigates it:

https://twitter.com/Perpetualmaniac/status/1224749841797926912 According to Chinese scientists, the Corona Virus attaches onto lung receptors that are five times more likely in Asian males:
https://biorxiv.org/content/10.1101/2020.01.26.919985v1.full
Also... white people are essentially immune because we have the acetylcholinase inhibitor against the virus.

Well if somebody on Twitter say so, it must be true.

Acetylcholinesterase inhibitors:[5]

Occur naturally as venoms and poisons (e.g onchidal)

https://en.wikipedia.org/wiki/Acetylcholinesterase_inhibitor
 
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Well if somebody on Twitter say so, it must be true.



https://en.wikipedia.org/wiki/Acetylcholinesterase_inhibitor
They cited the scientific study.

Here is the part about the 5X susceptible cells for you:


https://www.biorxiv.org/content/10.1....919985v1.full
... To further understand the special population of ACE2-expressing AT2, we performed gene ontology enrichment analysis to study which biological processes are involved with this cell population by comparing them with the AT2 cells not expressing ACE2. Surprisingly, we found that multiple viral process-related GO are significantly over-presented, including “positive regulation of viral process” (P value=0.001), “viral life cycle” (P value=0.005), “virion assembly” (P value=0.03) and “positive regulation of viral genome replication” (P value=0.04). These highly expressed viral process-related genes in ACE2-expressing AT2 include: SLC1A5, CXADR, CAV2, NUP98, CTBP2, GSN,HSPA1B,STOM, RAB1B, HACD3, ITGB6, IST1,NUCKS1,TRIM27, APOE, SMARCB1,UBP1,CHMP1A,NUP160,HSPA8,DAG1,STAU1,ICAM1, CHMP5,D EK, VPS37B, EGFR, CCNK, PPIA, IFITM3, PPIB, TMPRSS2, UBC, LAMP1 and CHMP3. Therefore, it seems that the 2019-nCov has cleverly evolved to hijack this population of AT2 cells for its reproduction and transmission.
We further compared the characteristics of the donors and their ACE2 expressing patterns. No association was detected between the ACE2-expressing cell number and the age or smoking status of donors. Of note, the 2 male donors have a higher ACE2-expressing cell ratio than all other 6 female donors (1.66% vs. 0.41% of all cells, P value=0.07, Mann Whitney Test). In addition, the distribution of ACE2 is also more widespread in male donors than females: at least 5 different types of cells in male lung express this receptor, while only 2~4 types of cells in female lung express the receptor. This result is highly consistent with the epidemic investigation showing that most of the confirmed 2019-nCov infected patients were men (30 vs. 11, by Jan 2, 2020).
We also noticed that the only Asian donor (male) has a much higher ACE2-expressing cell ratio than white and African American donors (2.50% vs. 0.47% of all cells). This might explain the observation that the new Coronavirus pandemic and previous SARS-Cov pandemic are concentrated in the Asian area.
 
China's central government has ordered Wuhan to round up all suspected coronavirus patients as well as their close contacts in mass quarantine camps.
The country's Vice Premier Sun Chunlan called on a 'people's war' against the fast-spreading epidemic, which has killed at least 638 people and infected more than 31,520 globally.
She demanded Communist officials of all levels take active lead in this 'wartime condition', or face being 'nailed onto the pillar of historical shame forever'.
The city has around 14 million residents, but it remains unknown how many people would be quarantined or where they would be kept.
Wuhan officials are now carrying out door-to-door health checks to identify potential carriers who would need to be isolated.


Ms Sun demanded four types of people in Wuhan be put into mandatory isolation in quarantine stations: confirmed cases, suspected cases, people who have close contact with the former two, and those who have fever.
Ms Sun called on a 'people's war' against the coronavirus epidemic in a meeting on Tuesday.
Yesterday, she instructed all levels of officials to treat the fight of the outbreak as the 'most important and urgent mission' in another briefing.
'There must be a 24-hour shift pattern. During the wartime condition, there must be no deserters, otherwise they will be forever nailed onto the pillar of historical shame', Ms Sun said, according to state broadcaster CCTV.
The Communist leader instructed the Wuhan government to send workers to every household to take the temperature of all family members in order to block the source of the outbreak.

More at: https://www.dailymail.co.uk/news/ar...ed-coronavirus-patients-quarantine-camps.html
 
They cited the scientific study.

Here is the part about the 5X susceptible cells for you:


https://www.biorxiv.org/content/10.1....919985v1.full
... To further understand the special population of ACE2-expressing AT2, we performed gene ontology enrichment analysis to study which biological processes are involved with this cell population by comparing them with the AT2 cells not expressing ACE2. Surprisingly, we found that multiple viral process-related GO are significantly over-presented, including “positive regulation of viral process” (P value=0.001), “viral life cycle” (P value=0.005), “virion assembly” (P value=0.03) and “positive regulation of viral genome replication” (P value=0.04). These highly expressed viral process-related genes in ACE2-expressing AT2 include: SLC1A5, CXADR, CAV2, NUP98, CTBP2, GSN,HSPA1B,STOM, RAB1B, HACD3, ITGB6, IST1,NUCKS1,TRIM27, APOE, SMARCB1,UBP1,CHMP1A,NUP160,HSPA8,DAG1,STAU1,ICAM1, CHMP5,D EK, VPS37B, EGFR, CCNK, PPIA, IFITM3, PPIB, TMPRSS2, UBC, LAMP1 and CHMP3. Therefore, it seems that the 2019-nCov has cleverly evolved to hijack this population of AT2 cells for its reproduction and transmission.
We further compared the characteristics of the donors and their ACE2 expressing patterns. No association was detected between the ACE2-expressing cell number and the age or smoking status of donors. Of note, the 2 male donors have a higher ACE2-expressing cell ratio than all other 6 female donors (1.66% vs. 0.41% of all cells, P value=0.07, Mann Whitney Test). In addition, the distribution of ACE2 is also more widespread in male donors than females: at least 5 different types of cells in male lung express this receptor, while only 2~4 types of cells in female lung express the receptor. This result is highly consistent with the epidemic investigation showing that most of the confirmed 2019-nCov infected patients were men (30 vs. 11, by Jan 2, 2020).
We also noticed that the only Asian donor (male) has a much higher ACE2-expressing cell ratio than white and African American donors (2.50% vs. 0.47% of all cells). This might explain the observation that the new Coronavirus pandemic and previous SARS-Cov pandemic are concentrated in the Asian area.

Thank you for the link. They also note their sample size is too small (just one Asian male plus seven other samples) to draw any useful conclusions.

A comparison between eight individual samples demonstrated that the Asian male one has an extremely large number of ACE2-expressing cells in the lung.

The shortcoming of the study is the small donor sample number, and that the current technique can only analyze the RNA level but not the protein level of single cells. Furthermore, it remains unknown whether there is any other co-receptor responsible for the 2019-nCov infection, which might also help to explain the observed difference of transmission ability between SARS-Cov and 2019-nCov.
 
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Thank you for the link. They also note their sample size is too small (just one Asian male) to draw any useful conclusions.
The difference in the spread rate in asia vs. elsewhere and the fact that many of the Americans and others in western countries who did catch were of asian ancestry would seem to back up the theory.
 
The difference in the spread rate in asia vs. elsewhere and the fact that many of the Americans and others in western countries who did catch were of asian ancestry would seem to back up the theory.

People outside Asia have been isolated from other people so it is not surprising that fewer are getting infected. US is quarantining people for at least two weeks. And the infected Americans are not all of Asian descent.
 
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#Coronavirus showing resistance to earlier antivirals. Researchers from Wuhan General Hospital, Pasteur Institute at Shanghai and Institute of Virology At Hubei are all concerned that the coronavirus seems to be evolving and becoming virulent and stronger. (Thailand Medical News) pic.twitter.com/hFL5jMrVBT
— Max Howroute▫️ (@howroute) February 6, 2020

 
Some patients get better and their fever resolves, and then all of a sudden their lung function collapses and they need oxygen:

 
From another site:


The following doesn't qualify as much more than a rumor, but it's the truth as far as I know. My brother and his Chinese wife are hosting a couple from China. The couple have a relative working in the Wuhan bioweapons lab, 8 miles from the market reputed to be ground zero of the epidemic. The couple left China in December, and are not planning to go back.

The story from inside the lab is that the virus came from laboratory animals. The animals were stolen from the facility by cleaning staff, who sold them in the market.

Someone mentioned the movie Contagion earlier today. We saw it a couple of nights ago. Eerie similarities with the current situation, including a virus, China as the source, and deadly consequences.
 
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