The comparison, if I'm correct, is regarding the decentralization of the federal government, see there were early rifts in the American government, one that wanted more power (Alexander Hamilton) and those who wanted it to be limited (Jefferson), this was illustrated, when Hamilton led the charge for a central bank, which was heavily opposed by Jefferson and James Madison. So I think this is where the comparison comes into play.
Hard to gauge the founders views on slavery, many of them owned slaves - a time where some people were not considered humans, slavery is a black mark on America, but all civilizations had slavery, so to harp on it is a little unfair IMO - besides, slavery will always exist, it's just called different things now and different devices are used to enslave the mind and body. I mean lets face it, the entire prison system is basically slavery, how much to prisoners manufacture making oh what 3 cents a day?