jmdrake
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https://www.ncbi.nlm.nih.gov/pmc/ar...fter 2 doses, those with,CoV-1–naive controls.
Key Points
Question
Does SARS-CoV-1 infection confer long-lasting memory immunity against the closely related SARS-CoV-2?
Findings
This cohort study of 12 participants with SARS-CoV-1 infection in 2003 showed robust antibody response at 7 days after receiving 1 dose of either inactivated or messenger RNA COVID-19 vaccine. After 2 doses, those with past SARS-CoV-1 infection developed significantly higher levels of neutralizing antibodies against wild-type SARS-CoV-2 and variants of concern compared with 40 sex- and age-matched SARS-CoV-1–naive controls.
Meaning
These findings suggest that cross-clade memory immunity persists long after natural infection with SARS-CoV-1, supporting the development of vaccines with a broad coverage to control pandemics due to coronaviruses.
That explains why countries like Taiwan and Japan had low COVID death rates without locking down. It could also explain China's initial low death rate. People credit China's "COVID zero" policy but when China finally opened up fully they had 1.4 million deaths in a month. But's COVID had mutated significantly by that time. In contrast by NOT locking down, Japan and Taiwan's populations were able to be exposed to the new variants as they evolved. Natural immunity FTW!
Key Points
Question
Does SARS-CoV-1 infection confer long-lasting memory immunity against the closely related SARS-CoV-2?
Findings
This cohort study of 12 participants with SARS-CoV-1 infection in 2003 showed robust antibody response at 7 days after receiving 1 dose of either inactivated or messenger RNA COVID-19 vaccine. After 2 doses, those with past SARS-CoV-1 infection developed significantly higher levels of neutralizing antibodies against wild-type SARS-CoV-2 and variants of concern compared with 40 sex- and age-matched SARS-CoV-1–naive controls.
Meaning
These findings suggest that cross-clade memory immunity persists long after natural infection with SARS-CoV-1, supporting the development of vaccines with a broad coverage to control pandemics due to coronaviruses.
That explains why countries like Taiwan and Japan had low COVID death rates without locking down. It could also explain China's initial low death rate. People credit China's "COVID zero" policy but when China finally opened up fully they had 1.4 million deaths in a month. But's COVID had mutated significantly by that time. In contrast by NOT locking down, Japan and Taiwan's populations were able to be exposed to the new variants as they evolved. Natural immunity FTW!
