Potential vaccine against Alzheimer’s show promise in mice

[Brian4Liberty]

Potential vaccine against Alzheimer’s show promise in mice

Potential vaccine against Alzheimer’s show promise in mice

A team of scientists have developed a vaccine that reduces Alzheimer’s symptoms in mice with features of the disease. The scientific journal, Molecular Psychiatry, published the discovery today (Monday 15 November).
...
Using two types of mice with features of Alzheimer’s disease, the scientists looked at the effect of injecting an antibody and engineered vaccine they developed.

The treatments target a shortened form of the hallmark Alzheimer’s protein, amyloid, which other Alzheimer’s drugs in development have not targeted.

What did they find?

Researchers looked at PET brain scans of the mice after treatment. They found treatment improved brain metabolism and also reduced the number of brain nerve cells lost.

They also found the mice performed better on a behavioural task.
...
More: https://www.alzheimersresearchuk.org/potential-vaccine-against-alzheimers-show-promise-in-mice/

 

[fisharmor]

So they're sure getting on top of that "vaccines are meant to reduce symptoms" narrative.

I wonder if they decided how many shots the mice need to be able to get food.

 

[acptulsa]

Mice get Alzheimer’s? Yes? No? You don't know, Alzheimer's is only accurately diagnosed when you can analyze speech?

So, you inject a chemical in a mouse, and decide it prevents Alzheimer's because...?

 

[Invisible Man]

With the changing definition of vaccine, now lots of new things can get called vaccines.

Soon, companies selling bottled water will start calling their water a vaccine, and be able to meet the government's definition.

 

[TheTexan]

With the changing definition of vaccine, now lots of new things can get called vaccines.

Soon, companies selling bottled water will start calling their water a vaccine, and be able to meet the government's definition.

Water has been proven to be 90% effective at preventing dehydration

 

[donnay]

One of the key elements causing Alzheimer's, that has been studied, is aluminum and the other is mercury. Aluminum salts are used and Thimerosal is made of thiosalicyclic acid and ethyl mercury and both are used as an adjuvant in vaccines.

Aluminum in the body has been cited as a likely contributing factor to both autoimmune conditions and other chronic illnesses ([8,9], 31,059,838; [10], 29,307,441; [11]; 27,908,630, [12]; 25,506,338). Person-to-person variation in whole body clearance rates due to genetics and environmental factors has been under-studied. Studies of human plasma or blood clearance rates ([13];15,152,306) offer little useful information to toxicology, for the known mechanisms of toxicity of aluminum are intracellular and are thus intra-tissue. Thus, rapid serum or blood clearance rates can be misleadingly reassuring when considering chronic or even acute toxicity of aluminum injected with vaccines. Aluminum in many forms has been long suspected of playing a role in Alzheimer’s disease ([14]; 26,494,454) and is supported by studies showing disease symptom reduction from ingestion of silicon-rich mineral waters ([15]; 22,976,072). “Tagging” of aluminum released by detoxification with compounds in chlorella and spirulina ([16]; 7,687,764; [17]s; 23,986,974) may be essential to allow removal by the liver, and to prevent “detox-retox” that occurs when aluminum is freed from cell death, redistributed and deposited via resequestration within and among tissues in the body.

Medically, proper organ, cellular and body aluminum detoxification appears to be of ever-increasing importance: Aluminum has been found in the brains of patients with Parkinson’s Disease ([18]; 29,189,118;[19]), Alzheimer’s disease (Mizra et al., 2017; 28,159,219), epilepsy ([20]; 31,208,130), and autism ([21]; 29,413,113). Evidence is growing that a host of chronic illnesses of unknown cause that are difficult to diagnose such as PANDAS/PANS([22]; 25,150,567; [23], 29,309,797), chronic fatigue syndrome ([24]; 31,394,725) may at least in part be due to vaccine aluminum intolerance ([10]; [9], 31,059,838; Crepeaux et al., 2018; 29525002, Crepeux et al., 2017; 27,908,630; [12]; 25,506,338).

https://www.sciencedirect.com/science/article/pii/S0946672X19305784

Thimerosal, which is present in most flu vaccines, is highly toxic and synergistically toxic, meaning it becomes significantly more toxic when in the presence of other chemical compounds such as aluminum and many antibiotics. Thimerosal is made of thiosalicyclic acid and ethyl mercury. Mercury is 500-1,000 times more toxic than lead. Paradoxically, pregnant women are told by their doctors to limit their seafood intake due to mercury concerns, but now, pregnant women are also told to get their mercury-containing flu shots.

If you’ve ever heard the saying “mad as a hatter,” it refers to the fact that mercury was once used in the making of fur hats. Hatters, those unfortunates souls who made fur hats, would often go insane due to mercury poisoning. Studies have linked high levels of mercury to Alzheimer’s disease. High levels of mercury has also been linked to autism, ADHD, and other learning disabilities and neurological impairments.

https://www.organiclifestylemagazin...ial-dangers-and-effectiveness-of-the-flu-shot

 

[Occam's Banana]

Water has been proven to be 90% effective at preventing dehydration

Known side effects include (but are not limited to) ruined picnics/vacations, slippery floors/roads, and occasional drowning.

Nasty stuff.

 

[RJB]

I would bet anyone that in 20 years, they will have findings that show that this vaccine caused Alzheimer.

 

[Brian4Liberty]

The actual study:

Discovery of a novel pseudo β-hairpin structure of N-truncated amyloid-β for use as a vaccine against Alzheimer’s disease

As far as creating a treatment, they have come up with a potential antibody treatment. This is a very common therapy. Any biological drug that has “ab” at the end is an antibody. Monoclonal antibody treatment seems to be effective against Covid.

The vaccine is different, as it would work in the manner of a traditional vaccine, which exposes your body to something that your body then learns to create it’s own antibodies against:

Importantly, TAP01 family antibodies that uniquely recognise this pseudo β-hairpin conformation are protective in AD animal models and furthermore do not interact with fibrillary forms of amyloid typically seen in plaques of AD brain sections (Fig. S8). This exciting finding reveals new opportunities for AD therapeutic intervention, with options for both therapeutic TAP01 family antibodies and vaccine development. To explore the potential of an innovative vaccine approach to AD we undertook a series of animal studies to determine if immunisation with a stabilised pseudo β-hairpin form of Aβ1-14 showed any protection in mouse models of AD and to compare potential beneficial affects to treatment with the humanised TAP01_04 antibody.
...
In conclusion, we have developed a novel AD vaccine with unique features not related to any other vaccine or antibody in clinical development. The TAPAS family antibodies are uniquely positioned as the antibodies selectively target the early toxic N-terminal truncated species of Aβ found in abundance throughout the brains of AD patients. Moreover, the TAP01 antibody – and its humanised versions – are less likely to become trapped inside plaques thereby increasing the bioavailability after passive immunisation. This decreases the potential for the dose-limiting side effects that have so far proved problematic in clinical trials of other Aβ antibodies. The novel TAPAS family of antibodies have revealed two new attractive options for therapeutic intervention in AD, with either active immunisation using a cyclised peptide based vaccine, or treatment with a humanised TAP01 family therapeutic antibody (passive immunisation). The lead therapeutic antibody for clinical assessment is TAP01_04, which is a humanised variant of TAP01 retaining the high specificity and affinity of the mouse parent antibody [10, 35]. The optimum antibody format, such as full-length or Fab fragment, safety, tolerability and efficacy of TAP01_04 will now need to be evaluated in carefully planned human clinical trials. For a trail blazing vaccine-based approach to AD, formulation of the candidate cyclised Aβ peptides is likely to be a key factor to ensure a strong immune response and will require expertise from specialist vaccine development organisations. The design of the TRAILBLAZER-ALZ phase II registration quality trial to evaluate safety, tolerability and efficacy of donanemab [52] will be helpful to design clinical trials targeting the TAPAS epitope. In TRAILBLAZER-ALZ early AD patients were recruited based on a medium tangle load using Tau-PET imaging. As donanemab completely cleared plaques in two-thirds of participants and slowed cognitive decline in some patients, the pathological status appears crucial for a successful treatment strategy. The positive therapeutic outcomes from active immunisation with cyclic Aβ1-14 as well as the passive immunisation with the clinical lead candidate antibody suggest the potential for a vaccine to protect future generations from this terrible disease.

In conclusion, they are working on 1) antibody therapy, and 2) a potential vaccine. It’s all hypothetical at this point. Don't hold your breath.

 

[acptulsa]

This is great because I have a neighbor who has this disease and she is very afraid of getting infected and rarely goes out because of it. She has been thinking about the vaccine for a long time and has not yet decided to make it. But I think soon she will do it then she will be safer than now as she is an older person and can have a very hard time with the disease. Thanks for this article!

She's afraid she'll be infected because she has Alzheimer's, spambot? That's different. Most of the people I've known who contracted it were mostly afraid of forgetting what words like "infected" mean.

How long before you add the link? Last time it took you over a week...

My dad needed better blood circulation so we started looking for effective ways. He can not play sports, so he tried to walk a lot and eat foods such as cinnamon, garlic, coconut oil, dark chocolate, green tea and so on. He also started taking vitamins from Online Pharmacy which also helped him well. My mom often do my dad a massage. Firstly, blood circulation improved and secondly, my father enjoyed it so much. There are many ways to improve blood circulation and everyone can choose what suits him best.

 

[pcosmar]

The Cure is already available.

https://www.webmd.com/alzheimers/news/20061006/marijuana-may-slow-alzheimers

Oct. 6, 2006 -- THC, the key compound in marijuana, may also be the key to new drugs for Alzheimer's disease.

That's because the marijuana compound blocks the formation of brain-clogging Alzheimer's plaques better than current Alzheimer's drugs.

"While we are certainly not advocating the use of illegal drugs, these findings offer convincing evidence that THC possesses remarkable inhibitory qualities, especially when compared to [Alzheimer's drugs] currently available to patients," Janda says in a news release.

"Although our study is far from final, it does show that there is a previously unrecognized molecular mechanism through which THC may directly affect the progression of Alzheimer's disease."

Janda's team found that THC blocks an enzyme called acetylcholinesterase, which speeds the formation of amyloid plaque in the brains of people with Alzheimer's disease.

 

[Anti Globalist]

Known side effects include (but are not limited to) ruined picnics/vacations, slippery floors/roads, and occasional drowning.

Nasty stuff.

Sounds like horrible side effects. We should ban water immediately.

 

[acptulsa]

This is great because I have a neighbor who has this disease and she is very afraid of getting infected and rarely goes out because of it. She has been thinking about the vaccine for a long time and has not yet decided to make it. But I think soon she will do it then she will be safer than now as she is an older person and can have a very hard time with the disease. Thanks for this article!

Your neighbor with Alzheimer's sounds like just the person I need to help me make my health decisions!